In utero exposure to both high- and low-dose diethylstilbestrol disrupts mouse genital tubercle development
| Autor: | Melanie K Stewart, Deidre M. Mattiske, Andrew J Pask |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Diethylstilbestrol Physiology Biology 03 medical and health sciences Mice 0302 clinical medicine Pregnancy medicine Endocrine system Animals Estrogens Non-Steroidal Genitalia Genital tubercle 030219 obstetrics & reproductive medicine Dose-Response Relationship Drug Drinking Water Anogenital distance Abnormalities Drug-Induced Cell Biology General Medicine medicine.disease Embryo Mammalian Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Reproductive Medicine Endocrine disruptor In utero Hypospadias Maternal Exposure Female Penis medicine.drug |
| Zdroj: | Biology of reproduction. 99(6) |
| ISSN: | 1529-7268 |
| Popis: | Exposure to estrogenic endocrine disrupting chemicals (EDCs) during in utero development has been linked to the increasing incidence of disorders of sexual development. Hypospadias, the ectopic placement of the urethra on the ventral aspect of the penis, is one of the most common DSDs affecting men, and can also affect women by resulting in the misplacement of the urethra. This study aimed to comprehensively assess the resulting hypospadias phenotypes in male and female mice exposed in utero from embryonic day 9.5 to 19.5 to the potent estrogenic endocrine disruptor, diethylstilbestrol, at a high, clinically relevant dose, and a low, previously untested dose, administered via water. The anogenital distance of male pups was significantly reduced and hypospadias was observed in males at a high frequency. Females exhibited hypospadias and urethral-vaginal fistula. These results demonstrate the ability of an estrogen receptor agonist to disrupt sexual development in both male and female mice, even at a low dose, administered via drinking water. |
| Databáze: | OpenAIRE |
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