Phosphine-Catalyzed (4 + 2) Cycloaddition of Conjugated Dienes with Enones and Its Asymmetric Variant
| Autor: | Zheng Duan, Erqing Li, Ke Li, Zhenjie Gan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
010405 organic chemistry
Dihydropyran Organic Chemistry Conjugated system 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Cycloaddition 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Zwitterion Phosphonium Physical and Theoretical Chemistry Phosphine |
| Zdroj: | Organic Letters. 23:3094-3099 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | Herein we reported a novel phosphine-catalyzed (4 + 2) cyclization reaction of electron-deficient conjugated dienes with enones to generate functionalized dihydropyran skeletons. A mechanistic investigation reveals that the reaction produces a new phosphonium zwitterion, which undergoes consecutive reactions. In addition, an asymmetric variant was developed by efficient and economical chiral phosphine catalysis. |
| Databáze: | OpenAIRE |
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