Autoantibodies in interstitial lung diseases
| Autor: | Brittany Stevenson, Andrew McLean-Tooke, Mina John, Grace Thompson, Christine Bundell, Monalyssa Watson, Elizabeth Klinken, Fiona Lake |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Extractable nuclear antigens Autoimmune Diseases Pathology and Forensic Medicine Serology 03 medical and health sciences 0302 clinical medicine Humans Rheumatoid factor Medicine Connective Tissue Diseases Myositis Aged Autoantibodies Retrospective Studies Aged 80 and over Autoimmune disease business.industry Autoantibody Interstitial lung disease Middle Aged medicine.disease Connective tissue disease 030104 developmental biology 030220 oncology & carcinogenesis Female Lung Diseases Interstitial business |
| Zdroj: | Pathology. 51:518-523 |
| ISSN: | 0031-3025 |
| DOI: | 10.1016/j.pathol.2019.03.007 |
| Popis: | The role of autoantibody testing for patients with interstitial lung disease is an evolving area. Recent guidelines recommend routine anti-nuclear antibodies, rheumatoid factor, and anti-citrullinated cyclic peptide antibody testing for patients undergoing diagnostic evaluation for interstitial lung disease, with further autoantibody testing reserved for selected cases guided by rheumatological features. Even this approach may miss patients with clinically significant autoantibodies when interstitial lung disease is the dominant or first manifestation of autoimmune disease. We retrospectively performed autoimmune serology in a clinically well characterised cohort of interstitial lung disease patients. Using stored serum, additional testing was performed to ensure all patients had complete autoantibody profiles including anti-nuclear antibodies, extractable nuclear antigen antibodies, double-stranded DNA antibodies, rheumatoid factor, anti-citrullinated cyclic peptide antibodies, anti-neutrophil cytoplasmic antibodies, and myositis antibodies. Eighty patients with interstitial lung disease, and available stored serum, were assessed. Mean age at interstitial lung disease diagnosis was 65.2 years and 42 patients were male. Positive autoimmune serology was found in 56 of 80 (70.0%) patients; the most common positive result was anti-nuclear antibodies (n=34; 42.5%). Myositis antibodies were detected in 13 of 80 (16.2%) patients. Four (5%) patients had elevated anti-citrullinated cyclic peptide antibodies, and two (2.5%) patients had detectable myeloperoxidase antibodies. Eleven (13.7%) patients with negative anti-nuclear antibodies had other significant disease associated autoantibodies. An extended panel of autoantibody testing may detect cases of connective tissue disease associated interstitial lung disease, regardless of clinical or radiological subtype, and prior to extra-pulmonary manifestations of systemic autoimmunity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect