Auditory Detection Thresholds and Cochlear Resistivity Differ Between Pediatric Cochlear Implant Listeners With Enlarged Vestibular Aqueduct and Those With Connexin-26 Mutations
| Autor: | Julie G Arenberg, Molly D Bergan, Kelly N. Jahn |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Hearing loss Hearing Loss Sensorineural medicine.medical_treatment Connexin Audiology Connexins Vestibular Aqueduct 03 medical and health sciences Speech and Hearing 0302 clinical medicine Cochlear implant Electric Impedance otorhinolaryngologic diseases medicine Humans Child 030223 otorhinolaryngology Research Articles business.industry Auditory Threshold Signal Processing Computer-Assisted medicine.disease Cochlear Implantation Cochlea Connexin 26 Cochlear Implants Female sense organs medicine.symptom business 030217 neurology & neurosurgery Enlarged vestibular aqueduct |
| Zdroj: | Am J Audiol |
| ISSN: | 1558-9137 1059-0889 |
| DOI: | 10.1044/2019_aja-19-00054 |
| Popis: | Purpose The goal of this study was to evaluate differences in the electrode–neuron interface as a function of hearing loss etiology in pediatric cochlear implant (CI) listeners with enlarged vestibular aqueduct (EVA) syndrome and in those with autosomal recessive connexin-26 mutations (DFNB1). Method Fifteen implanted ears (9 participants, 5 ears with EVA, 10 ears with DFNB1) were assessed. Single-channel auditory detection thresholds were measured using broad and spatially focused electrode configurations (steered quadrupolar; focusing coefficients = 0 and 0.9). Cochlear resistivity estimates were obtained via electrode impedances and electrical field imaging. Between-group differences were evaluated using linear mixed-effects models. Results Children with EVA had significantly higher auditory detection thresholds than children with DFNB1, irrespective of electrode configuration. Between-group differences in thresholds were more pronounced on apical electrodes than on basal electrodes. In the apex, electrode impedances and electrical field imaging values were higher for children with EVA than for those with DFNB1. Conclusions The electrode–neuron interface differs between pediatric CI listeners with DFNB1 and those with EVA. It is possible that optimal clinical interventions may depend, in part, on hearing loss etiology. Future investigations with large samples should investigate individualized CI programming strategies for listeners with EVA and DFNB1. |
| Databáze: | OpenAIRE |
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