Prolonged visual memory enhancement after direct current stimulation in Alzheimer's disease
| Autor: | Oscar Martins, Alberto Priori, Débora Martins, Maurizio Vergari, L. Tadini, Roberta Ferrucci, Paulo S. Boggio, Elio Scarpini, F. Mameli, Felipe Fregni |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Biophysics Stimulation tDCS lcsh:RC321-571 memory Physical medicine and rehabilitation Visual memory Alzheimer Disease medicine Humans Effects of sleep deprivation on cognitive performance lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Aged Aged 80 and over Temporal cortex Memory Disorders Transcranial direct-current stimulation General Neuroscience Cognition Transcranial Magnetic Stimulation Temporal Lobe Treatment Outcome medicine.anatomical_structure Pattern Recognition Visual Cerebral cortex Scalp Physical therapy Female Neurology (clinical) Psychology brain polarization Alzheimer’s disease |
| Zdroj: | Brain Stimulation, Vol 5, Iss 3, Pp 223-230 (2012) |
| Popis: | Background Immediately after patients with Alzheimer's disease (AD) receive a single anodal transcranial direct current stimulation (tDCS) session their memory performance improves. Whether multiple tDCS sessions improve memory performance in the longer term remains unclear. Objective In this study we aimed to assess memory changes after five consecutive sessions of anodal tDCS applied over the temporal cortex in patients with AD. Methods A total of 15 patients were enrolled in two centers. Cognitive functions were evaluated before and after therapeutic tDCS. tDCS was delivered bilaterally through two scalp anodal electrodes placed over the temporal regions and a reference electrode over the right deltoid muscle. The stimulating current was set at 2 mA intensity and was delivered for 30 minutes per day for 5 consecutive days. Results After patients received tDCS, their performance in a visual recognition memory test significantly improved. We found a main effect of tDCS on memory performance, i.e., anodal stimulation improved it by 8.99% from baseline, whereas sham stimulation decreased it by 2.62%. tDCS failed to influence differentially general cognitive performance measures or a visual attention measure. Conclusions Our findings show that after patients with AD receive anodal tDCS over the temporal cerebral cortex in five consecutive daily sessions their visual recognition memory improves and the improvement persists for at least 4 weeks after therapy. These encouraging results provide additional support for continuing to investigate anodal tDCS as an adjuvant treatment for patients with AD. |
| Databáze: | OpenAIRE |
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