Alopecia areata in Tunisia: epidemio-clinical aspects and comorbid conditions. A prospective study of 204 cases
| Autor: | Colandane Belajouza, Najet Ghariani, Wafa Saidi, Lobna Boussofara, Amina Aounallah, Rima Gammoudi, Aycha Arousse, Rafia Nouira, Sana Mokni, Mohamed Denguezli |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Tunisia Alopecia Areata Dermatology Vitiligo Comorbidity Lichen sclerosus Severity of Illness Index Autoimmune Diseases 030207 dermatology & venereal diseases 03 medical and health sciences Nail Diseases Young Adult 0302 clinical medicine Sex Factors Recurrence Risk Factors medicine Prevalence Humans Prospective Studies Age of Onset skin and connective tissue diseases Ophiasis integumentary system business.industry Alopecia totalis Alopecia areata medicine.disease Hair loss 030220 oncology & carcinogenesis Alopecia universalis Female Age of onset business |
| Zdroj: | International journal of dermatology. 58(7) |
| ISSN: | 1365-4632 |
| Popis: | BACKGROUND Alopecia areata (AA) is an autoimmune condition that usually presents as patchy, nonscarring hair loss. Autoimmune disorders and atopy are reported as comorbid conditions. We aimed to investigate the demographics, clinical characteristics, and associations of AA in Tunisian patients. METHODS Demographic data, pattern of alopecia, age of onset, and associations were evaluated in 204 patients from January 2012 to June 2016. RESULTS Two hundred and four cases of AA were seen. The male to female ratio was 0.68. The mean age at presentation was 23 years old. Positive family history was noticed in 22.1% of patients. Personal history of atopy was associated with AA in 18.1%. Associated autoimmune diseases were thyroid disorders (12.7%), vitiligo (1.5%), psoriasis (three cases), type 1 diabetes (two cases), autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) syndrome (two cases), lichen sclerosus atrophicus (one case), and pemphigus vulgaris (one case). Patchy AA was the most common manifestation (49.5%) followed by alopecia universalis (27.5%), alopecia ophiasis (12.7%), and alopecia totalis (10.3%). Nail changes consisting of pitting, trachyonychia, and longitudinal ridging were reported in 24.8%. AA patterns were more severe in females (P = 0.049). Severe forms showed more persistent disease duration (P = 0.005), earlier onset (P = 0.001), and more recurring episodes (P = 0.002) and were significantly associated with nail involvement (P < 0.001). CONCLUSIONS Our study aimed to review epidemio-clinical characteristics and comorbid conditions of AA in Tunisian patients. More severe cases with a pejorative value of early-onset AA, long disease duration, and nail involvement were seen in our study. |
| Databáze: | OpenAIRE |
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