Evaluation of placental oxygenation index using blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) during normal late pregnancy
| Autor: | Naosuke Enomoto, Tomoaki Ikeda, Eiji Kondo, Shinichi Takase, Masafumi Nii, Ryohei Nakayama, Hajime Sakuma, Hiroaki Tanaka, Shoichi Magawa, Masaki Ishida |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Oxygenation index Placenta chemistry.chemical_element Hyperoxia Oxygen 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine medicine Humans Birth Weight 030219 obstetrics & reproductive medicine Blood-oxygen-level dependent medicine.diagnostic_test business.industry Infant Newborn Obstetrics and Gynecology Magnetic resonance imaging Oxygenation Magnetic Resonance Imaging Late pregnancy 030104 developmental biology chemistry Oxygen Saturation Pediatrics Perinatology and Child Health Cardiology Female business |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 35:5274-5281 |
| ISSN: | 1476-4954 1476-7058 |
| Popis: | Noninvasive blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) has recently been used to evaluate placental oxygenation. However, this method still has unresolved problems, such as long testing times and lack of normal values set. In the present study, we used a shorter protocol in BOLD-MRI and established normal values for placental oxygenation in late pregnancy.We recruited 18 healthy singleton pregnant women (32 weeks of gestation) who had a normal body size before pregnancy and a normal course of pregnancy. They underwent BOLD-MRI with three consecutive 4-min periods of different oxygenation: normoxia (21% OIn all cases, the BOLD signal was elevated by maternal oxygen administration, with the peak resolving within 4 min after the end of oxygen administration. Peak ΔR2* and time to peak ΔR2* during oxygenation were 7.99 ± 2.58, and 458.1 ± 73.9 s, respectively. There was a significant correlation between peak ΔR2* and neonatal birth weight (percentile) (In all cases, the BOLD signal increased with maternal hyperoxia using this protocol. So, 4 min observation following maternal oxygen administration is sufficient for peak ΔR2* evaluation. These reference values set in this study may be one of the indicators of BOLD signal changes in normal pregnancies after 32 weeks of gestation. |
| Databáze: | OpenAIRE |
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