Acute control of the sleep switch in Drosophila reveals a role for gap junctions in regulating behavioral responsiveness
| Autor: | Kelly Munro, Michael Troup, Benjamin Kottler, Melvyn H.W. Yap, Paul J Shaw, Bruno van Swinderen, Deniz Ertekin, Chelsie E. Rohrscheib, Aoife Larkin, Martyna J. Grabowska, Roshini Randeniya |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
QH301-705.5 Science Innexin Optogenetics Biology Connexins General Biochemistry Genetics and Molecular Biology Arousal 03 medical and health sciences Electrical Synapses whole-cell patch Animals Drosophila Proteins Homeostasis Wakefulness sleep Biology (General) optogenetics Neurons Neural correlates of consciousness D. melanogaster General Immunology and Microbiology Mechanism (biology) behavior General Neuroscience fungi Brain General Medicine innexin electrophysiology Sleep in non-human animals Electrophysiology Drosophila melanogaster 030104 developmental biology Gene Expression Regulation Medicine Neuroscience Research Article |
| Zdroj: | eLife, Vol 7 (2018) eLife |
| Popis: | Sleep is a dynamic process in most animals, involving distinct stages that probably perform multiple functions for the brain. Before sleep functions can be initiated, it is likely that behavioral responsiveness to the outside world needs to be reduced, even while the animal is still awake. Recent work in Drosophila has uncovered a sleep switch in the dorsal fan-shaped body (dFB) of the fly’s central brain, but it is not known whether these sleep-promoting neurons also govern the acute need to ignore salient stimuli in the environment during sleep transitions. We found that optogenetic activation of the sleep switch suppressed behavioral responsiveness to mechanical stimuli, even in awake flies, indicating a broader role for these neurons in regulating arousal. The dFB-mediated suppression mechanism and its associated neural correlates requires innexin6 expression, suggesting that the acute need to reduce sensory perception when flies fall asleep is mediated in part by electrical synapses. |
| Databáze: | OpenAIRE |
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