The correlation between serum E-selectin levels and soluble interleukin-2 receptors with relation to disease activity in localized scleroderma
| Autor: | Natalia Salwowska, Dominika Wcisło-Dziadecka, Karolina Wodok-Wieczorek, Aleksandra Wodok, Ewa Syguła, Ligia Brzezińska-Wcisło, Beata Bergler-Czop, Katarzyna Bebenek |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
lcsh:Internal medicine Dermatology Disease Gastroenterology Scleroderma Serology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Fibrosis Statistical significance Internal medicine lcsh:Dermatology Immunology and Allergy Medicine Localized Scleroderma lcsh:RC31-1245 030203 arthritis & rheumatology Original Paper medicine.diagnostic_test business.industry selectin E-selectin lcsh:RL1-803 medicine.disease Connective tissue disease connective tissue disease interleukin-2 receptors Skin biopsy business localized scleroderma |
| Zdroj: | Advances in Dermatology and Allergology, Vol 35, Iss 6, Pp 614-619 (2018) Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii |
| ISSN: | 2299-0046 |
| Popis: | Introduction Scleroderma is a chronic connective tissue disease resulting in fibrosis. Aim The aim of the study was to determine the connection between sE-selectin and sIL-2R and the severity of skin lesions in various subtypes of LoS. Evaluation of disease severity, the location of skin lesions, the duration of symptoms and disease activity were assessed in relation to the three different LoS subtypes in patients with localized scleroderma. Material and methods The study included 42 patients with localized scleroderma and the control group consisted of 41 healthy subjects. All patients in the LoS study group had a confirmed diagnosis via skin biopsy and underwent serology testing for sE-selectin and sIL-2R concentrations by enzyme-linked immunosorbent assay (ELISA). Results Significantly higher levels of sE-selectin and sIL-2R were observed in the LoS study group when compared with the control group (p < 0.001). The analysis showed a result close to statistical significance (p = 0.058) between sE-selectin concentration during the time of active disease in the LoS study group. The highest concentrations of sE-selectin and sIL-2R were observed in patients with the generalized subtype of LoS. A positive, statistically significant, curvilinear relationship was shown amid the modified Localized Skin Severity Index (mLoSSI) and sE-selectin and sIL-2R concentrations in the LoS study group. Conclusions Concentrations of the circulating form of sE-selectin appear to be an adequate marker of the endothelial function, positively correlating with the severity of the disease. The proven correlation of sIL-2R concentrations with the severity of the disease indicates that it is a valuable prognostic factor for predicting the impending course of the disease. |
| Databáze: | OpenAIRE |
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