Correction factor between two calcitonin assays: DiaSorin LiaisonXL and Cobas E601
| Autor: | Andra Caragheorgheopol, Stefana Bucur, Mara Baetu, Adriana Padure, Alexandru Draghici, Corin Badiu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry liaisonxl food and beverages cobase601 030209 endocrinology & metabolism 030204 cardiovascular system & hematology correction factor 03 medical and health sciences 0302 clinical medicine Endocrinology Calcitonin medullary thyroid carcinoma Internal medicine calcitonin medicine Medicine business |
| Zdroj: | Romanian Journal of Laboratory Medicine, Vol 29, Iss 3, Pp 271-276 (2021) |
| ISSN: | 2284-5623 |
| Popis: | Introduction: Calcitonin measurement is important for the diagnosis and monitoring of medullary thyroid carcinoma. Unfortunately, in clinical practice, different detection systems assays are used in the follow-up of the patients, which can be misleading. Objective: To identify the correction factor for calcitonin measurement on two different immunoanalysers: DiaSorin-LiaisonXL (immunochemiluminescence) and CobasE601 (electro-immunochemiluminescence). Methods: We selected 89 registered CT samples (28-from men; 61-from women), that were analysed on CobasE601 with reported values between 0.5 pg/ml and 2812 pg/ml (128.5±513.98). These CT samples were selected randomly to cover as wide a range of values as possible, and represented either basal CT (n=38) or selected from CT stimulation tests (n=51). Samples were evaluated subsequently on DiaSorin-LiaisonXL. All patients gave their informed consent. Results: Between the two assays a segmented linear correlation was noted. We identified the following general linear regression equation: 1.108x+19.337 (p Conclusions: Calcitonin correction factors are highly important in the dynamic follow up of a patient suffering from medullary thyroid carcinoma when different detection systems assays are used to determine calcitonin. We identified the correction factors for calcitonin determination between two different frequently used chemiluminescence immunoanalysers: DiaSorin-LiaisonXL and CobasE601. However, it is strongly advisable to use the same analyser in order to establish biochemical evolution of calcitonin. |
| Databáze: | OpenAIRE |
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