Change in location of cytokine-induced neutrophil chemoattractants (CINCs) in pulmonary silicosis
| Autor: | Hiroshi Uno, Hiroaki Mitsuhashi, Kumiko Aoki, Junko Hata |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Pathology medicine.medical_specialty Chemokine Time Factors Lipopolysaccharide Neutrophils Chemokine CXCL1 medicine.medical_treatment Silicosis Clinical Biochemistry Inflammation Pathology and Forensic Medicine chemistry.chemical_compound medicine Animals Lung Molecular Biology Chemotactic Factors biology business.industry Granuloma Foreign-Body Silicon Dioxide medicine.disease Immunohistochemistry Rats Cytokine medicine.anatomical_structure chemistry Granuloma Models Animal Immunology biology.protein Intercellular Signaling Peptides and Proteins Chemokines medicine.symptom business Chemokines CXC |
| Zdroj: | Experimental and Molecular Pathology. 75:68-73 |
| ISSN: | 0014-4800 |
| DOI: | 10.1016/s0014-4800(03)00029-7 |
| Popis: | Rat cytokine-induced neutrophil chemoattractants (CINCs), which belong to the interleukin-8 family, are known to be induced by treatment with lipopolysaccharide (LPS). Recently, CINCs were grouped into four subtypes-CINC-1, CINC-2alpha, CINC-2beta, and CINC-3-and CINC-1 was considered to be a major isoform among the four CINCs in LPS-induced acute lung inflammation in rats. The purpose of this study was to investigate the change in location of CINCs with chronic inflammation induced by experimental pulmonary silicosis. Administration of silica particles induced lung granulomas. Immunohistochemical staining for CINCs showed that the number of cells positive for CINC-2alpha, CINC-2beta, and CINC-3 was increased, peaking at 1 day after treatment with silica particles, whereas CINC-1 was almost undetectable. We suggest that CINC-2alpha, CINC-2beta, and CINC-3 are the most important chemoattractants in the formation of granulomas in chronic inflammation. |
| Databáze: | OpenAIRE |
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