Antibacterial Polyurethane Foams with Incorporated Lignin-Capped Silver Nanoparticles for Chronic Wound Treatment
| Autor: | A. Gala Morena, Miguel Sánchez-Soto, Ivaylo Stefanov, Kristina Ivanova, Sílvia Pérez-Rafael, Tzanko Tzanov |
|---|---|
| Přispěvatelé: | Universitat Politècnica de Catalunya. Doctorat en Polímers i Biopolímers, Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials, Universitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial, Universitat Politècnica de Catalunya. e-PLASCOM - Plàstics i Compòsits Ecològics |
| Rok vydání: | 2020 |
| Předmět: |
Chronic wound
Plata Materials science General Chemical Engineering Polimerització Polímers -- Deterioració macromolecular substances 02 engineering and technology Silve complex mixtures Industrial and Manufacturing Engineering Silver nanoparticle Polymerization Absorption chemistry.chemical_compound Biopolymers Enginyeria química [Àrees temàtiques de la UPC] 020401 chemical engineering medicine Lignin 0204 chemical engineering Polyurethane Nanopartícules integumentary system Organic polymers technology industry and agriculture food and beverages Polymers -- Deterioration Foams General Chemistry 021001 nanoscience & nanotechnology chemistry Chemical engineering Materials biomèdics Nanoparticles medicine.symptom Absorption (chemistry) 0210 nano-technology Biomedical materials |
| Zdroj: | UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) |
| ISSN: | 1520-5045 0888-5885 |
| Popis: | Lignin-capped silver nanoparticles were incorporated in situ into polyurethane foams during their polymerization to obtain multifunctional materials suitable for chronic wound dressing. Lignin with increased phenolic content, achieved through the enzymatic grafting of natural phenolic compounds, played the dual role of a silver reducing agent in the synthesis of the lignin-capped silver nanoparticles and as a nanoformulated polyol additive in the polyurethane composition able to react with isocyanate. The nanoparticles-embedded polyurethane foams showed over 4 and 5 logs bacterial growth reduction against the Gram-positive S. aureus and the Gram-negative P. aeruginosa, respectively, attributed to both the direct contact- and release-killing mechanisms. The swelling properties of the foams, related to their capacity to remove the excess of wound exudates containing deleterious oxidative species and enzymes, varied from 585 to 1145 % as a function of the content of nanoparticles. Overall, the physicomechanical and antibacterial properties of the foams, together with their biocompatibility and sustained release of silver, make these multifunctional materials suitable candidates for chronic wound dressings. |
| Databáze: | OpenAIRE |
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