Fibroblasts in the Infarcted, Remodeling, and Failing Heart
| Autor: | Nikolaos G. Frangogiannis, Claudio Humeres |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
ROCK Rho-associated coiled-coil containing kinase lcsh:Diseases of the circulatory (Cardiovascular) system Angiogenesis extracellular matrix infarction Diastole Infarction miRNA micro–ribonucleic acid Inflammation 030204 cardiovascular system & hematology Biology STATE-OF-THE-ART REVIEW MRTF myocardin-related transcription factor fibroblast PDGF platelet-derived growth factor Extracellular matrix 03 medical and health sciences 0302 clinical medicine ROS reactive oxygen species Fibrosis medicine AT1 angiotensin type 1 Fibroblast TGF transforming growth factor remodeling Genetic heterogeneity lncRNA long noncoding ribonucleic acid medicine.disease cytokines Cell biology ECM extracellular matrix FGF fibroblast growth factor IL interleukin 030104 developmental biology medicine.anatomical_structure lcsh:RC666-701 FAK focal adhesion kinase RNA ribonucleic acid SMA smooth muscle actin medicine.symptom Cardiology and Cardiovascular Medicine MAPK mitogen-activated protein kinase TRP transient receptor potential |
| Zdroj: | JACC: Basic to Translational Science JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 449-467 (2019) |
| ISSN: | 2452-302X |
| Popis: | Highlights • Cardiac fibroblasts become activated following injury and participate in repair and remodeling of the heart. • The authors discuss the phenotypic alterations and role of fibroblasts in infarcted and failing hearts. • In failing hearts, fibroblasts may deposit ECM proteins, increasing myocardial stiffness, but may also exert protective and reparative actions. • Future studies will focus on characterization of the phenotypic heterogeneity of cardiac fibroblasts that may explain their functional diversity. Summary Expansion and activation of fibroblasts following cardiac injury is important for repair but may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the dynamic alterations of fibroblasts in failing and remodeling myocardium. Emerging concepts suggest that fibroblasts are not unidimensional cells that act exclusively by secreting extracellular matrix proteins, thus promoting fibrosis and diastolic dysfunction. In addition to their involvement in extracellular matrix expansion, activated fibroblasts may also exert protective actions, preserving the cardiac extracellular matrix, transducing survival signals to cardiomyocytes, and regulating inflammation and angiogenesis. The functional diversity of cardiac fibroblasts may reflect their phenotypic heterogeneity. Central Illustration |
| Databáze: | OpenAIRE |
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