Impact of Renal Impairment on Beta-Blocker Efficacy in Patients With Heart Failure

Autor: Jane Holmes, Milton Packer, Marcus Flather, Thomas G. von Lueder, Giuseppe M.C. Rosano, John Wikstrand, Kevin Damman, John J.V. McMurray, Frank Ruschitzka, John G.F. Cleland, Michael Böhm, Dipak Kotecha, Simrat Gill, Hans Wedel, Andrew J.S. Coats, John Kjekshus, Josep Redon, Bert Andersson, Stefan D. Anker, Dirk J. van Veldhuisen, Alan S. Rigby, Luis Manzano
Přispěvatelé: Cardiovascular Centre (CVC), University of Zurich, Kotecha, Dipak
Rok vydání: 2019
Předmět:
Male
BASE-LINE
Comorbidity
030204 cardiovascular system & hematology
Ventricular Function
Left
0302 clinical medicine
II CIBIS-II
RANDOMIZED INTERVENTION TRIAL
Interquartile range
Cause of Death
Sinus rhythm
030212 general & internal medicine
Renal Insufficiency
Ejection fraction
Hazard ratio
Atrial fibrillation
Middle Aged
Prognosis
Survival Rate
INSIGHTS
CARDIAC-INSUFFICIENCY BISOPROLOL
10209 Clinic for Cardiology
Cardiology
SURVIVAL
Disease Progression
Female
Cardiology and Cardiovascular Medicine
Glomerular Filtration Rate
renal impairment
medicine.medical_specialty
medicine.drug_class
Adrenergic beta-Antagonists
METOPROLOL
Renal function
610 Medicine & health
2705 Cardiology and Cardiovascular Medicine
EJECTION FRACTION
03 medical and health sciences
beta-blockers
Double-Blind Method
Internal medicine
medicine
Humans
Beta blocker
Aged
Heart Failure
CARVEDILOL
business.industry
Stroke Volume
medicine.disease
mortality
Heart failure
ATRIAL-FIBRILLATION
business
Zdroj: Journal of the American College of Cardiology, 74(23), 2893-2904. ELSEVIER SCIENCE INC
ISSN: 1558-3597
0735-1097
Popis: Background:\ud Moderate and moderately severe renal impairment are common in patients with heart failure and reduced ejection fraction, but whether beta-blockers are effective is unclear, leading to underuse of life-saving therapy.\ud \ud Objectives:\ud This study sought to investigate patient prognosis and the efficacy of beta-blockers according to renal function using estimated glomerular filtration rate (eGFR).\ud \ud Methods:\ud Analysis of 16,740 individual patients with left ventricular ejection fraction
Databáze: OpenAIRE
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