Clarifying the role of sleep in depression: A narrative review
| Autor: | Jaime M. Monti, Seithikurippu R. Pandi-Perumal, Gregory M. Brown, David Warren Spence, Ramanujam Karthikeyan, Meera Narashimhan, Deepa Burman, Ahmed S. BaHammam |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Sleep Wake Disorders medicine.medical_treatment Population 03 medical and health sciences 0302 clinical medicine Biological Clocks medicine Insomnia Animals Humans education Biological Psychiatry Depression (differential diagnoses) Depressive Disorder Major education.field_of_study Depression business.industry Chronotherapy (sleep phase) medicine.disease Circadian Rhythm 030227 psychiatry Obstructive sleep apnea Psychiatry and Mental health Hypomania Major depressive disorder Female medicine.symptom Sleep business Mania 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Psychiatry Research. 291:113239 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/j.psychres.2020.113239 |
| Popis: | It has been established that 4.4 to 20% of the general population suffers from a major depressive disorder (MDD), which is frequently associated with a dysregulation of normal sleep-wake mechanisms. Disturbances of circadian rhythms are a cardinal feature of psychiatric dysfunctions, including MDD, which tends to indicate that biological clocks may play a role in their pathophysiology. Thus, episodes of depression and mania or hypomania can arise as a consequence of the disruption of zeitgebers (time cues). In addition, the habit of sleeping at a time that is out of phase with the body's other biological rhythms is a common finding in depressed patients. In this review, we have covered a vast area, emerging from human and animal studies, which supports the link between sleep and depression. In doing so, this paper covers a broad range of distinct mechanisms that may underlie the link between sleep and depression. This review further highlights the mechanisms that may underlie such link (e.g. circadian rhythm alterations, melatonin, and neuroinflammatory dysregulation), as well as evidence for a link between sleep and depression (e.g. objective findings of sleep during depressive episodes, effects of pharmacotherapy, chronotherapy, comorbidity of obstructive sleep apnea and depression), are presented. |
| Databáze: | OpenAIRE |
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