Neutrophil function, nitric oxide, and blood oxidative stress in Parkinson's disease
| Autor: | Natalia A. Riobo, Manuel Fernandez Pardal, Marisa G. Repetto, Emilia Gatto, Susana Llesuy, Juan José Poderoso, Claudia Reides, Maria Cecilia Carreras, Griselda A. Pargament |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Erythrocytes Parkinson's disease Free Radicals Neutrophils Neutrophile Stimulation Nitric Oxide medicine.disease_cause Nitric oxide Antiparkinson Agents Levodopa Pathogenesis chemistry.chemical_compound Internal medicine Humans Medicine chemistry.chemical_classification Reactive oxygen species biology Superoxide Dismutase business.industry Carbidopa Parkinson Disease Hydrogen Peroxide Middle Aged Catalase medicine.disease Oxidative Stress Endocrinology Neurology chemistry Luminescent Measurements Immunology biology.protein Drug Therapy Combination Female Neurology (clinical) Reactive Oxygen Species business Oxidative stress |
| Zdroj: | Movement Disorders. 11:261-267 |
| ISSN: | 1531-8257 0885-3185 |
| DOI: | 10.1002/mds.870110308 |
| Popis: | We studied nitrogen radical nitric oxide (.NO) release and reactive oxygen species (ROS) production by isolated neutrophils after phorbol myristate acetate (PMA) stimulation in 12 newly diagnosed and nine treated Parkinson's disease (PD) patients and 10 age-matched healthy controls. Neutrophils of both groups of PD patients had an elevated PMA-activated release of .NO [61 and 57%, respectively, higher than that of controls (p < 0.05)]. In contrast, H2O2 release was only significantly increased by 56% in chronically treated patients. In agreement, the maximum rate of luminol-dependent chemiluminescence, which partly represents O2- H2O2- .NO interactions, was increased only in the treated group. When other blood markers of oxidative stress were compared, only erythrocyte catalase activity was decreased in both PD patient series by 33 and 39%, respectively (p < 0.05), whereas plasma antioxidant capacity and erythrocyte superoxide dismutase activity levels were decreased only in treated PD patients. This study suggests that neutrophils express a primary alteration of .NO release in PD patients, whereas H2O2 and oxidative-stress parameters are more probably related to the evolution of PD or to effects of treatment with L-dopa. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text