Clinical evaluation of Duraflo® II heparin treated extracorporeal circulation circuits (2nd version) The European working group on heparin coated extracorporeal circulation circuits
Autor: | Leon Eijsman, P. D. Bezemer, Thore H Pedersen, Jan L. Svennevig, L. K. Von Segesser, T. Tkebuchava, C. Baufreton, D. Y. Loisance, A. O'Donnell, J. D. Biervliet, J.L. Pomar, F. W. J. Van Hardevelt, V. Videm, L. Bellaiche, E. Thörnö, D. J. Kuik, B. Mohr, H. H. Kure, P. Bruins, M. Van Dyck, A. Ponlot-Lois, A. McCarthy, H. Karlsen, John Michael Hasenkam, Oddvar Moen, G. Bajan, E. Conti, A. Ditta, P. Le Besnerais, C. Anderson, E. Ahlvin, Stefan Thelin, E. A. McGovern, M. Ranucci, M. Th Renotte, J. McCarthy, E. Haldén, B. M. Weiss, Amine Matta, Erik Fosse, Einar Dregelid, Vibeke Brockmeier, Ch. R. H. Wildevuur, D. Conti, L. Hagman, A. P. De Jong, P. Ahlburg, S. Cirri, P. G M Jansen, Ph Baele, M. I. Turina, Lars Knudsen |
---|---|
Přispěvatelé: | VU University medical center, Faculteit der Geneeskunde |
Rok vydání: | 1997 |
Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Extracorporeal Circulation medicine.medical_specialty Surface Properties medicine.drug_class Blood Loss Surgical Coronary Disease law.invention Postoperative Complications law Intensive care medicine Cardiopulmonary bypass Humans Coronary Artery Bypass Adverse effect Aged Heparin business.industry Extracorporeal circulation Anticoagulant General Medicine Middle Aged Survival Analysis Cardiac surgery Surgery Clinical trial Treatment Outcome Anesthesia Female Cardiology and Cardiovascular Medicine business medicine.drug |
Zdroj: | European Journal of Cardio-thoracic Surgery, 11(4), 616-623. Elsevier European journal of cardio-thoracic surgery, 11, 616-623. Elsevier Wildevuur, C R H, Jansen, P G M, Bezemer, P D, Kuik, D J, Eijsman, L, Bruins, P, de Jong, A P, Vanhardevelt, F W J, Biervliet, J D, Hasenkam, J M, Kure, H H & Knudsen, L 1997, ' Clinical Evaluation of Duraflo(r) II Heparin treated Extracorporeal Circulation Circuits (2nd version)-The European Working Group on Heparin Coated Extracorporeal Circulation Circuits ', European Journal of Cardio-thoracic Surgery, vol. 11, no. 4, pp. 616-623 . https://doi.org/10.1016/S1010-7940(96)01122-0 |
ISSN: | 1010-7940 |
Popis: | To evaluate whether the application of heparin treated circuits for elective coronary artery surgery improves postoperative recovery, a European multicenter randomised clinical trial was carried out.In 11 European heart centers, 805 low-risk patients underwent cardiopulmonary bypass (CPB) with either an untreated circuit (n = 407) or an identical but heparin treated circuit (n = 398, Duraflo II).Significant differences were found among participating centers with respect to patient characteristics, blood handling procedures and postoperative care. The use of heparin treated circuits revealed no overall changes in blood loss, blood use, time on ventilator, occurrence of adverse events, morbidity, mortality, and intensive care stay. These results did not change after adjustment for centers and (other) prognostic factors as analysed with logistic regression. In both groups no clinical or technical (patient or device related) side effects were reported. Because female gender and aortic cross clamp time appeared as prognostic factors in the logistic regression analysis, a subgroup analysis with these variables was performed. In a subpopulation of females (n = 99), those receiving heparin treated circuits needed less blood products, had a lower incidence of rhythm disturbances and were extubated earlier than controls. In another subgroup of patients with aortic cross clamp time exceeding 60 min (n = 197), the amount of patients requiring prolonged intensive care treatment (24 h) was significantly lower when they received heparin treated circuits versus controls.These findings suggest that improved recovery can be expected with heparin treated circuits in specific higher risk patient populations (e.g. females) and when prolonged aortic cross clamp time is anticipated. Further investigations are recommended to analyses the clinical benefit of heparin treated circuits in studies with patients in different well defined risk categories and under better standardised circumstances. |
Databáze: | OpenAIRE |
Externí odkaz: |