The phosphoenolpyruvate-dependent glucose–phosphotransferase system from Escherichia coli K-12 as the center of a network regulating carbohydrate flux in the cell
| Autor: | Ariane Staab, Elisabeth Gabor, Anne Kosfeld, Andreas Kremling, Anna-Katharina Göhler, Knut Jahreis |
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| Rok vydání: | 2011 |
| Předmět: |
Histology
Carbohydrate transport Escherichia coli K12 Glucose transporter Catabolite repression macromolecular substances Cell Biology General Medicine PEP group translocation Biology Pathology and Forensic Medicine Phosphorylation cascade carbohydrates (lipids) Phosphotransferase stomatognathic diseases Biochemistry Membrane protein otorhinolaryngologic diseases Carbohydrate Metabolism bacteria Phosphorylation Phosphoenolpyruvate Sugar Phosphotransferase System Integral membrane protein Signal Transduction |
| Zdroj: | European Journal of Cell Biology. 90:711-720 |
| ISSN: | 0171-9335 |
| Popis: | The phosphoenolpyruvate-(PEP)-dependent-carbohydrate:phosphotransferase systems (PTSs) of enteric bacteria constitute a complex transport and sensory system. Such a PTS usually consists of two cytoplasmic energy-coupling proteins, Enzyme I (EI) and HPr, and one of more than 20 different carbohydrate-specific membrane proteins named Enzyme II (EII), which catalyze the uptake and concomitant phosphorylation of numerous carbohydrates. The most prominent representative is the glucose-PTS, which uses a PTS-typical phosphorylation cascade to transport and phosphorylate glucose. All components of the glucose-PTS interact with a large number of non-PTS proteins to regulate the carbohydrate flux in the bacterial cell. Several aspects of the glucose-PTS have been intensively investigated in various research projects of many groups. In this article we will review our recent findings on a Glc-PTS-dependent metalloprotease, on the interaction of EIICB(Glc) with the regulatory peptide SgrT, on the structure of the membrane spanning C-domain of the glucose transporter and on the modeling approaches of ptsG regulation, respectively, and discuss them in context of general PTS research. |
| Databáze: | OpenAIRE |
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