High prevalence of dyslipidaemia subtypes and their associated personal and clinical attributes in Malaysian adults: the REDISCOVER study
Autor: | Nor-Ashikin Mohamed Noor Khan, Mohamed-Syarif Mohamed-Yassin, Noorhida Baharudin, Anis Safura Ramli, Aqil M. Daher, Najmin Abu Bakar, Suraya Abdul-Razak, Mariam Mohamad, Khalid Yusoff |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
lcsh:Diseases of the circulatory (Cardiovascular) system Dyslipidaemia 030309 nutrition & dietetics Comorbidity 030204 cardiovascular system & hematology Overweight Logistic regression 0302 clinical medicine Risk Factors Prevalence Prospective Studies Prospective cohort study Hypercholesterolaemia Non-HDL-c 0303 health sciences Age Factors Middle Aged Lipids Obesity Abdominal Hypertension lipids (amino acids peptides and proteins) HDL-c Female medicine.symptom Cardiology and Cardiovascular Medicine Research Article Adult medicine.medical_specialty Risk Assessment 03 medical and health sciences Internal medicine Diabetes mellitus medicine Diabetes Mellitus Humans Life Style Triglycerides Angiology Dyslipidemias business.industry Malaysia nutritional and metabolic diseases Anthropometry medicine.disease Obesity Blood pressure Cross-Sectional Studies lcsh:RC666-701 business LDL-c Biomarkers |
Zdroj: | BMC Cardiovascular Disorders BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-13 (2021) |
ISSN: | 1471-2261 |
Popis: | Background Dyslipidaemia refers to lipid abnormalities consisting of either one or any combination of the following: elevated total cholesterol (TC), elevated low-density lipoprotein cholesterol (LDL-c), elevated triglycerides (TG), and low high-density lipoprotein cholesterol (HDL-c). The prevalence of hypercholesterolaemia is steadily increasing in Malaysia. However, data on the prevalence of dyslipidaemia subtypes among Malaysians are lacking. This is important as it may have implications for preventive and management strategies for this increasing public health challenge. This study is aimed at determining the prevalence of dyslipidaemia subtypes and their associated personal and clinical attributes in Malaysians. Methods REDISCOVER, a prospective study, enrolled 11,288 adults where sociodemographic data, anthropometric and blood pressure measurements, fasting lipid profile and glucose, and history of diabetes, hypertension, and smoking were obtained. The cross-sectional analytic sample presented in this article comprised 10,482 participants from baseline recruitment. The data was analysed by descriptive statistics and multivariable logistic regression. Results The overall prevalence of elevated TC, elevated LDL-c, elevated TG, low HDL-c, and elevated non-HDL-c were 64.0% (95% CI 63.0–65.0), 56.7% (CI 55.7–57.7), 37.4% (CI 36.5–38.4), 36.2% (CI 35.2–37.1), and 56.2% (CI 55.3–57.2), respectively. Overweight, obesity, and central obesity were highly prevalent and significantly associated with elevated TC and all dyslipidaemia subtypes. Older age was associated with elevated TC, elevated LDL-c and elevated non-HDL-c. Hypertension was associated with elevated TC, elevated TG, and elevated non-HDL-c, while diabetes was associated with elevated TG and low HDL-c. Conclusions Elevated TC and all dyslipidaemia subtypes are highly prevalent in Malaysia where increased body mass seems the main driver. Differences in the prevalence and associated personal and clinical attributes may facilitate specific preventive and management strategies. |
Databáze: | OpenAIRE |
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