High prevalence of dyslipidaemia subtypes and their associated personal and clinical attributes in Malaysian adults: the REDISCOVER study

Autor: Nor-Ashikin Mohamed Noor Khan, Mohamed-Syarif Mohamed-Yassin, Noorhida Baharudin, Anis Safura Ramli, Aqil M. Daher, Najmin Abu Bakar, Suraya Abdul-Razak, Mariam Mohamad, Khalid Yusoff
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Dyslipidaemia
030309 nutrition & dietetics
Comorbidity
030204 cardiovascular system & hematology
Overweight
Logistic regression
0302 clinical medicine
Risk Factors
Prevalence
Prospective Studies
Prospective cohort study
Hypercholesterolaemia
Non-HDL-c
0303 health sciences
Age Factors
Middle Aged
Lipids
Obesity
Abdominal
Hypertension
lipids (amino acids
peptides
and proteins)
HDL-c
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
Research Article
Adult
medicine.medical_specialty
Risk Assessment
03 medical and health sciences
Internal medicine
Diabetes mellitus
medicine
Diabetes Mellitus
Humans
Life Style
Triglycerides
Angiology
Dyslipidemias
business.industry
Malaysia
nutritional and metabolic diseases
Anthropometry
medicine.disease
Obesity
Blood pressure
Cross-Sectional Studies
lcsh:RC666-701
business
LDL-c
Biomarkers
Zdroj: BMC Cardiovascular Disorders
BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-13 (2021)
ISSN: 1471-2261
Popis: Background Dyslipidaemia refers to lipid abnormalities consisting of either one or any combination of the following: elevated total cholesterol (TC), elevated low-density lipoprotein cholesterol (LDL-c), elevated triglycerides (TG), and low high-density lipoprotein cholesterol (HDL-c). The prevalence of hypercholesterolaemia is steadily increasing in Malaysia. However, data on the prevalence of dyslipidaemia subtypes among Malaysians are lacking. This is important as it may have implications for preventive and management strategies for this increasing public health challenge. This study is aimed at determining the prevalence of dyslipidaemia subtypes and their associated personal and clinical attributes in Malaysians. Methods REDISCOVER, a prospective study, enrolled 11,288 adults where sociodemographic data, anthropometric and blood pressure measurements, fasting lipid profile and glucose, and history of diabetes, hypertension, and smoking were obtained. The cross-sectional analytic sample presented in this article comprised 10,482 participants from baseline recruitment. The data was analysed by descriptive statistics and multivariable logistic regression. Results The overall prevalence of elevated TC, elevated LDL-c, elevated TG, low HDL-c, and elevated non-HDL-c were 64.0% (95% CI 63.0–65.0), 56.7% (CI 55.7–57.7), 37.4% (CI 36.5–38.4), 36.2% (CI 35.2–37.1), and 56.2% (CI 55.3–57.2), respectively. Overweight, obesity, and central obesity were highly prevalent and significantly associated with elevated TC and all dyslipidaemia subtypes. Older age was associated with elevated TC, elevated LDL-c and elevated non-HDL-c. Hypertension was associated with elevated TC, elevated TG, and elevated non-HDL-c, while diabetes was associated with elevated TG and low HDL-c. Conclusions Elevated TC and all dyslipidaemia subtypes are highly prevalent in Malaysia where increased body mass seems the main driver. Differences in the prevalence and associated personal and clinical attributes may facilitate specific preventive and management strategies.
Databáze: OpenAIRE
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