Hexahistidine-metal assemblies: A promising drug delivery system
| Autor: | Xingjie Zan, Pengyan Hao, Bo Peng, Tinghong Zhang, Wenjuan Huang, Hao Chen, Jianghui Qin, Shan Luo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Drug
media_common.quotation_subject 0206 medical engineering Biomedical Engineering Antineoplastic Agents 02 engineering and technology Endocytosis Biochemistry Biomaterials Coordination Complexes Neoplasms medicine Humans Histidine Internalization Cytotoxicity Molecular Biology media_common Chemistry General Medicine 021001 nanoscience & nanotechnology 020601 biomedical engineering Delayed-Action Preparations Drug delivery Biophysics Nanomedicine Camptothecin Lysosomes 0210 nano-technology Intracellular HeLa Cells Biotechnology medicine.drug |
| Zdroj: | Acta Biomaterialia. 90:441-452 |
| ISSN: | 1742-7061 |
| DOI: | 10.1016/j.actbio.2019.03.058 |
| Popis: | It is of considerable interest to construct an ideal drug delivery system (i.e., high drug payload, minimal cytotoxicity, rapid endocytosis, and lysosomal escape) under mild conditions for disease treatment, tissue engineering, bioimaging, etc. Inspired by the coordinative interactions between histidine and metal ions, we present the facile synthesis of hexahistidine (His6)-metal assembly (HmA) particles under mild conditions for the first time. The HmA particles presented a high loading capacity, a wide variety of loadable drugs, minimal cytotoxicity, quick internalization, the ability to bypass the lysosomes, and rapid intracellular drug release. In addition, HmA encapsulation largely improved the antitumor ability of camptothecin (CPT) relative to free CPT. By capitalizing on these promising features in drug delivery, HmA will have great potential in various biomedical fields. STATEMENT OF SIGNIFICANCE: It is of considerable interest to construct an ideal drug delivery system (i.e., high drug payload, minimal cytotoxicity, rapid endocytosis, and lysosomal escape) under mild conditions. Inspired by the coordinative interactions between histidine and metal ions, we present for the first time the facile synthesis of Hexahistidine (His6)-metal assembly (HmA) particles under mild conditions. The HmA particles exhibited a high loading capacity, a wide variety of loadable drugs, minimal cytotoxicity, quick internalization, the ability to bypass the lysosomes, and rapid intracellular drug release. By capitalizing on these promising features in drug delivery, HmA will have great potential in various biomedical fields. |
| Databáze: | OpenAIRE |
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