Self-Reported Real-World Safety and Reactogenicity of COVID-19 Vaccines: A Vaccine Recipient Survey
| Autor: | Nawar Diar Bakerly, Alexander G. Mathioudakis, Shazaad Ahmad, Lida Pieretta Papavasileiou, Murad Ghrew, Raymond Borrow, Andrew Ustianowski, Dimitrios Petrakis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
safety
medicine.medical_specialty Side effect reactogenicity 030204 cardiovascular system & hematology General Biochemistry Genetics and Molecular Biology Coronavirus Disease 2019 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine 030212 general & internal medicine tolerability Adverse effect lcsh:Science Ecology Evolution Behavior and Systematics Reactogenicity business.industry Incidence (epidemiology) Brief Report Paleontology COVID-19 Confidence interval adverse events Vaccination Tolerability Space and Planetary Science Relative risk lcsh:Q business COVID-19 vaccine |
| Zdroj: | Life Life, Vol 11, Iss 249, p 249 (2021) |
| ISSN: | 2075-1729 |
| Popis: | An online survey was conducted to compare the safety, tolerability and reactogenicity of available COVID-19 vaccines in different recipient groups. This survey was launched in February 2021 and ran for 11 days. Recipients of a first COVID-19 vaccine dose ≥7 days prior to survey completion were eligible. The incidence and severity of vaccination side effects were assessed. The survey was completed by 2002 respondents of whom 26.6% had a prior COVID-19 infection. A prior COVID-19 infection was associated with an increased risk of any side effect (risk ratio 1.08, 95% confidence intervals (1.05–1.11)), fever (2.24 (1.86–2.70)), breathlessness (2.05 (1.28–3.29)), flu-like illness (1.78 (1.51–2.10)), fatigue (1.34 (1.20–1.49)) and local reactions (1.10 (1.06–1.15)). It was also associated with an increased risk of severe side effects leading to hospital care (1.56 (1.14–2.12)). While mRNA vaccines were associated with a higher incidence of any side effect (1.06 (1.01–1.11)) compared with viral vector-based vaccines, these were generally milder (p < 0.001), mostly local reactions. Importantly, mRNA vaccine recipients reported a considerably lower incidence of systemic reactions (RR < 0.6) including anaphylaxis, swelling, flu-like illness, breathlessness and fatigue and of side effects requiring hospital care (0.42 (0.31–0.58)). Our study confirms the findings of recent randomised controlled trials (RCTs) demonstrating that COVID-19 vaccines are generally safe with limited severe side effects. For the first time, our study links prior COVID-19 illness with an increased incidence of vaccination side effects and demonstrates that mRNA vaccines cause milder, less frequent systemic side effects but more local reactions. |
| Databáze: | OpenAIRE |
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