Development of a nomogram model to predict survival outcomes in patients with primary hepatic neuroendocrine tumors based on SEER database

Autor: Zhiwei Li, Zi-Teng Zhang, Xin Zhao, Youchun Wu, Guo-Bao Li, Yao Liu, Zhiyan Li
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Kaplan-Meier Estimate
Neuroendocrine tumors
Malignancy
Risk Assessment
Primary hepatic neuroendocrine tumors (PH-NETs)
Young Adult
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Surgical oncology
Internal medicine
Genetics
medicine
Humans
Nomogram model
Survival rate
RC254-282
Aged
Neoplasm Staging
Retrospective Studies
Univariate analysis
Receiver operating characteristic
business.industry
Research
Liver Neoplasms
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Middle Aged
Nomogram
medicine.disease
SEER database
Survival Rate
Transplantation
Neuroendocrine Tumors
Nomograms
Liver
ROC Curve
030220 oncology & carcinogenesis
Female
030211 gastroenterology & hepatology
business
Follow-Up Studies
SEER Program
Zdroj: BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
BMC Cancer
ISSN: 1471-2407
Popis: Background Primary hepatic neuroendocrine tumors (PH-NETs) are extremely rare and unknown. Because of its rarity, its prognosis features and influencing factors are not well established. Methods Data of 140 patients with PH-NETs diagnosed in the SEER database from 1975 to 2016 were collected. The demographics and clinic-pathological features were described. By using propensity-score matching (PSM) analysis, three associated cohorts were selected to describe the malignancy of PH-NETs and univariate analysis was conducted. Then, multivariate Cox analyses were performed and a predicting nomograph was constructed. C-index, receiver operating characteristic (ROC) curve and calibration curves were used to evaluate the predictive value of nomogram. Results The overall survival outcomes of PH-NETs were superior to hepatocellular carcinoma (HCC) with a mean survival time 30.64 vs 25.11 months (p = 0.052), but inferior to gastrointestinal tract neuroendocrine tumors in situ (GI-NETs in situ) with a mean survival time 30.64 vs 41.62 months (p = 0.017). With reference to gastrointestinal neuroendocrine tumors with liver metastasis (GI-NETs-LM), GI-NETs-LM had better outcomes in short time (1-year survival rate: 64.75% vs 56.43%) but was worse in long time (5-year survival rate: 8. 63% vs 18.57%). Multivariate Cox analyses showed that tumor grade and surgery were two independent factors for prognosis of the patients (p Conclusions The overall prognosis PH-NETs is generally favorable, better than HCC and GI-NETs-LM in long term. Preoperative biopsy and complete pathological diagnosis were recommended. Radical surgical intervention including transplantation was the first choice in PH-NETs therapy.
Databáze: OpenAIRE
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