Dose-response of somatosensory cortex repeated anodal transcranial direct current stimulation on vibrotactile detection : A randomized sham controlled trial
| Autor: | Brookes Folmli, Peter Johnson, Allan Abbott, Bulent Turman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Fysiologi Physiology medicine.medical_treatment Vibration detection Somatosensory system Transcranial Direct Current Stimulation Vibration 050105 experimental psychology law.invention 03 medical and health sciences Young Adult 0302 clinical medicine vibrotactile detection threshold Randomized controlled trial primary somatosensory cortex law Physical Stimulation medicine Humans 0501 psychology and cognitive sciences Sensory cortex Transcranial direct-current stimulation business.industry General Neuroscience 05 social sciences Somatosensory Cortex medicine.anatomical_structure Touch Perception Touch Sensory Thresholds Female Transcranial direct current stimulation business Neuroscience 030217 neurology & neurosurgery |
| Popis: | This randomized sham-controlled trial investigated anodal transcranial direct current stimulation (tDCS) over the somatosensory cortex contralateral to hand dominance for dose-response (1 mA, 20 min × 5 days) effects on vibrotactile detection thresholds (VDT). VDT was measured before and after tDCS on days 1, 3, and 5 for low- (30 Hz) and high-frequency (200 Hz) vibrations on the dominant and nondominant hands in 29 healthy adults (mean age = 22.86 yr; 15 men, 14 women). Only the dominant-hand 200-Hz VDT displayed statistically significant medium effect size improvement for mixed-model analysis of variance time-by-group interaction for active tDCS compared with sham. Post hoc contrasts were statistically significant for dominant-hand 200-Hz VDT on day 5 after tDCS compared with day 1 before tDCS, day 1 after tDCS, and day 3 before tDCS. There was a linear dose-response improvement with dominant-hand 200-Hz VDT mean difference decreasing from day 1 before tDCS peaking at −15.5% (SD = 34.9%) on day 5 after tDCS. Both groups showed learning effect trends over time for all VDT test conditions, but only the nondominant-hand 30-Hz VDT was statistically significant ( P = 0.03), although post hoc contrasts were nonsignificant after Šidák adjustment. No adverse effects for tDCS were reported. In conclusion, anodal tDCS at 1 mA, 20 min × 5 days on the dominant sensory cortex can modulate a linear improvement of dominant-hand high-frequency VDT but not low-frequency or nondominant-hand VDT. NEW & NOTEWORTHY Repeated weak anodal transcranial direct current stimulation (1 mA, 20 min) on the dominant sensory cortex provides linear improvement in dominant-hand high-frequency vibration detection thresholds. No effects were observed for low-frequency or nondominant-hand vibration detection thresholds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|