Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity?
| Autor: | Pavel Mericka, Anatoliy N. Goltsev, Mark W. Lowdell, Julie Kerby, Glyn Stacey, Olena Rogulska, Barry Fuller, Iryna Buriak, Alexander Y. Petrenko, Roland A. Fleck, Yuri Petrenko, Alexandra Stolzing, Maooz Awan |
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| Rok vydání: | 2020 |
| Předmět: |
Embryology
Cryobiology Cryoprotectant Cell Survival dimethyl sulfoxide Biomedical Engineering Context (language use) Pharmacology cryopreservation Cryopreservation 03 medical and health sciences chemistry.chemical_compound Cryoprotective Agents Medicine Animals Humans In patient Dimethyl Sulfoxide cryobiology 030304 developmental biology cryoprotectant toxicity 0303 health sciences cryoprotectants Tissue Engineering business.industry Dimethyl sulfoxide cell therapy safety 030302 biochemistry & molecular biology medicine.anatomical_structure chemistry Toxicity DMSO toxicity Bone marrow cell therapy business |
| Zdroj: | Regenerative medicine. 15(3) |
| ISSN: | 1746-076X |
| Popis: | Awan M, Buriak I, Fleck R, Fuller B, Goltsev A, Kerby J, Lowdell M, Mericka P, Petrenko A, Petrenko Y, Rogulska O, Stolzing A, Stacey GN. Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity? Regen Med. 2020 Mar;15(3):1463-1491. doi: 10.2217/rme-2019-0145. Epub 2020 Apr 28. PMID: 32342730. Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bone marrow and blood cells until needed for transfusion. Nevertheless, its effects on cell biology and apparent toxicity in patients have been an ongoing topic of debate, driving the search for less cytotoxic cryoprotectants. This review seeks to place the toxicity of DMSO in context of its effectiveness. It will also consider means of reducing its toxic effects, the alternatives to its use and their readiness for active use in clinical settings. |
| Databáze: | OpenAIRE |
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