Antiviral Activity of 3-(3,5-Dimethylbenzyl)Uracil Derivatives Against Hiv-1 and HCMV

Autor:	Graciella Andrei, Yosuke Demizu, Tokumi Maruyama, Christophe Pannecouque, Myriam Witvrouw, Jan Balzarini, Shigetada Kozai, Robert Snoecks, Erik De Clercq
Rok vydání:	2007
Předmět:	Human cytomegalovirus Adenosine Human immunodeficiency virus (HIV) Cytomegalovirus medicine.disease_cause Antiviral Agents Biochemistry chemistry.chemical_compound Genetics medicine Humans Amino acid residue Uracil Nucleoside analogue Reverse-transcriptase inhibitor virus diseases General Medicine medicine.disease Virology Reverse transcriptase chemistry HIV-1 Molecular Medicine Ribonucleosides medicine.drug
Zdroj:	Nucleosides, Nucleotides and Nucleic Acids. 26:1553-1558
ISSN:	1532-2335 1525-7770
DOI:	10.1080/15257770701545424
Popis:	Antiviral activity of 1,3-disubstituted uracil derivatives was evaluated against HIV-1 and HCMV. It appears that the nitrogen of the 1-cyanomethyl group is important for anti-HIV-1 activity, suggesting interaction with the amino acid residues of HIV-1 reverse transcriptase. 1-Arylmethyl derivatives also exhibited good anti-HIV-1 activity; and that of the 2- and 4-picolyl derivatives was particularly excellent.
Databáze:	OpenAIRE
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