SARS-CoV-2 IgG Antibodies Seroprevalence and Sera Neutralizing Activity in MEXICO: A National Cross-Sectional Study during 2020
| Autor: | Angel Gustavo Salas-Lais, Larissa Fernandes-Matano, Teresita Rojas-Mendoza, Iliana Donají Palomec-Nava, Víctor Hugo Borja-Aburto, Andrea Santos Coy-Arechavaleta, José Esteban Muñoz-Medina, Vanessa Rivero-Arredondo, Clara Esperanza Santacruz-Tinoco, Concepción Grajales-Muñiz, Ruth Lizzeth Madera-Sandoval, Constantino López-Macías, César González-Bonilla, J. E. Alvarado-Yaah, Irma Eloisa Monroy-Muñoz, Celida Duque-Molina, Joaquín González-Ibarra |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Cross-sectional study Population serology Microbiology Article Serology Herd immunity 03 medical and health sciences 0302 clinical medicine Virology Internal medicine antibody neutralization medicine clinical laboratory Seroprevalence herd immunity education lcsh:QH301-705.5 COVID-19 blood bank CLIA ELISA education.field_of_study Transmission (medicine) business.industry Incidence (epidemiology) Respiratory infection 030104 developmental biology lcsh:Biology (General) 030220 oncology & carcinogenesis business |
| Zdroj: | Microorganisms Microorganisms, Vol 9, Iss 850, p 850 (2021) Microorganisms; Volume 9; Issue 4; Pages: 850 |
| ISSN: | 2076-2607 |
| Popis: | Until recently, the incidence of COVID-19 was primarily estimated using molecular diagnostic methods. However, the number of cases is vastly underreported using these methods. Seroprevalence studies estimate cumulative infection incidences and allow monitoring of transmission dynamics, and the presence of neutralizing antibodies in the population. In February 2020, the Mexican Social Security Institute began conducting anonymous unrelated sampling of residual sera from specimens across the country, excluding patients with fever within the previous two weeks and/or patients with an acute respiratory infection. Sampling was carried out weekly and began 17 days before Mexico’s first officially confirmed case. The 24,273 sera obtained were analyzed by chemiluminescent-linked immunosorbent assay (CLIA) IgG S1/S2 and, later, positive cases using this technique were also analyzed to determine the rate of neutralization using the enzyme-linked immunosorbent assay (ELISA). We identified 40 CLIA IgG positive cases before the first official report of SARS-CoV-2 infection in Mexico. The national seroprevalence was 3.5% in February and 33.5% in December. Neutralizing activity among IgG positives patients during overall study period was 86.1%. The extent of the SARS-CoV-2 infection in Mexico is 21 times higher than that reported by molecular techniques. Although the general population is still far from achieving herd immunity, epidemiological indicators should be re-estimated based on serological studies of this type. |
| Databáze: | OpenAIRE |
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