Use of propylic ester of p-hydroxy-benzoic acid after removal of impacted mandibular third molars
| Autor: | O. Donatsky, P. Vedtofte, M. Ritzau |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Male Molar Pericoronitis Antifibrinolytic Adolescent medicine.drug_class Dry Socket Dentistry Alveolitis sicca dolorosa Placebo Placebos chemistry.chemical_compound Sex Factors Hydroxybenzoates medicine Humans In patient Child General Dentistry Aged Benzoic acid Clinical Trials as Topic business.industry Age Factors Tooth Impacted Esters Middle Aged medicine.disease Dry socket Otorhinolaryngology chemistry Tooth Extraction Female Surgery business |
| Zdroj: | International Journal of Oral Surgery. 3:394-399 |
| ISSN: | 0300-9785 |
| DOI: | 10.1016/s0300-9785(74)80004-9 |
| Popis: | A double blind study was carried out to investigate the prophylactic effect of an alveolar cone containing propylic ester of phydroxy-benzoic acid (PEHB) on the development of alveolitis sicca dolorosa (ASD) in relation to sex and pericoronitis. Three cones, each, containing 3 mg PEHB and 52 mg tablet mass or three placebo cones containing tablet mass only, were inserted in the socket after removal of impacted mandibular third molars. The material consisted of 144 consecutive patients, 76 females and 68 males. A significantly smaller number of ASD was found in the PEHB group in males (P = 0.01). No effect of PEHB could be demonstrated in the female group. No difference was found between PEHB and placebo in patients who had experienced preoperative symptoms. In the male group of patients without preoperative symptoms, significantly fewer cases of ASD developed after treatment with PEHB (P = 0.01). Such an effect was not found in the female group. No side effects were recorded in any of the cases. The results indicate that PEHB, under certain circumstances, may have such an antifibrinolytic effect in vivo that it may hinder a breakdown of the coagulum. |
| Databáze: | OpenAIRE |
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