Clinical Impact of Circulating Irisin on Classified Coronary Plaque Characteristics
| Autor: | Kazuhiro Harada, Toyoaki Murohara, Yohei Shibata, Toshijiro Aoki, Akihito Tanaka, Ryosuke Kikuchi, Kenshi Hirayama, Susumu Suzuki, Takuya Sumi, Hideki Ishii, Yosuke Tatami, Yosuke Negishi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty biology medicine.diagnostic_test business.industry medicine.medical_treatment Area under the curve Percutaneous coronary intervention General Medicine Myostatin 030204 cardiovascular system & hematology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Internal medicine Myokine Intravascular ultrasound medicine biology.protein Cardiology Circumflex business Hormone Artery |
| Zdroj: | The Journal of Applied Laboratory Medicine. 3:79-88 |
| ISSN: | 2475-7241 |
| DOI: | 10.1373/jalm.2017.025296 |
| Popis: | Background Myokines are hormones secreted by skeletal muscles during physical activity. Low myokine levels may contribute to metabolic dysfunction and cardiovascular disorders. Irisin, a newly identified myokine, has been the focus of recent research. The aim of the present study was to analyze the association between circulating irisin levels and tissue characteristics of nonculprit left main coronary artery (LMCA) plaques with the use of integrated backscatter (IB) intravascular ultrasound (IVUS). Methods This observational study enrolled 55 Japanese patients following successful percutaneous coronary intervention for lesions in the left anterior descending arteries or left circumflex arteries. Circulating myokine levels, including myostatin, brain-derived neurotrophic factor, and irisin, were measured by an enzyme-linked immunosorbent assay. Tissue characteristics of LMCA plaque were evaluated by IB-IVUS. Results Circulating irisin levels were negatively associated with percent lipid volume (%LV) [r = −0.31 (95% CI, −2.52 to −0.21), P = 0.02] and positively associated with percent fibrous volume (%FV) [r = 0.32 (95% CI, 0.22–2.20), P = 0.02]. The optimal cutoff value of circulating irisin for the prediction of lipid-rich LMCA plaques was 6.02 μg/mL [area under the curve = 0.713, P < 0.01 (95% CI, 0.58–0.85)]. Multivariate linear regression analysis identified circulating irisin levels as independent predictors for %LV and %FV of the LMCA [β = −0.29 (95% CI, −2.53 to −0.07), P = 0.04 and β = 0.30 (95% CI, 0.10–2.23), P = 0.03, respectively]. Conclusions Circulating irisin levels are significantly associated with tissue characteristics of nonculprit LMCA plaques. |
| Databáze: | OpenAIRE |
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