Loss of E-cadherin expression correlates with poor differentiation and invasion into adjacent organs in gastric adenocarcinomas
| Autor: | Jau-Yeong Lu, Hui-Hwa Tseng, Ching-Jiunn Tseng, Ming-Shyan Huang, Hui-Chun Chen, Nan-Hua Chou, Ping-Ning Hsu, Michael Hsiao, Ping-I Hsu, Ricky Yuan-Yuan Chu, Kwok-Hung Lai |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Cellular differentiation Adenocarcinoma Biology Metastasis Stomach Neoplasms medicine Humans Neoplasm Invasiveness Cadherin Stomach Cancer Cell Differentiation Middle Aged Cadherins Prognosis medicine.disease Immunohistochemistry Survival Rate medicine.anatomical_structure Oncology Tumor progression Female |
| Zdroj: | Cancer Letters. 201:97-106 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2003.07.007 |
| Popis: | Perturbation in E-cadherin expression leads to loss of cellular adhesion with possible consequence of cellular transformation and tumor progression. The aims of this study were to determine E-cadherin expression in each subtype of gastric cancer classified by different classification systems, and to investigate the role of E-cadherin in cell differentiation, cancer invasion and metastasis. Expression of E-cadherin was analyzed in 84 patients with gastric adenocarcinoma by immunohistochemistry and correlated with clinicopahotlogical parameters. Our results showed loss of E-cadherin expression in 0% (0/3), 20.0% (9/45), 48% (15/31), 100% (3/3) and 100% (2/2) of papillary, tubular, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma by Japanese histological classification. The reduction of E-cadherin expression was inversely correlated with the grade of differentiation. According to the histological classification of Lauren and Ming, the frequency of lost E-cadherin expression was higher in diffuse type (65%) and infiltrative type (64%) gastric cancer than in intestinal type (20%, P |
| Databáze: | OpenAIRE |
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