Biotransformation of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent, in rat liver microsomes
| Autor: | Milan Stefek, L. Turi-Nagy, L. Benes, M. Jergelova, P. Kocis, V. Ščasnár |
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| Rok vydání: | 1987 |
| Předmět: |
Male
Cardiotonic Agents Chromatography Gas Magnetic Resonance Spectroscopy Health Toxicology and Mutagenesis In Vitro Techniques Toxicology Biochemistry Gas Chromatography-Mass Spectrometry Rat liver microsomes Pharmacokinetics Biotransformation Animals Cardioprotective Agent Pharmacology biology Chemistry Rats Inbred Strains General Medicine Metabolism biology.organism_classification In vitro Rats Microsoma Microsomes Liver Microsome Chromatography Thin Layer Anti-Arrhythmia Agents Carbolines |
| Zdroj: | Xenobiotica. 17:1067-1073 |
| ISSN: | 1366-5928 0049-8254 |
| DOI: | 10.3109/00498258709044205 |
| Popis: | 1. The metabolism of stobadine, a gamma-carboline antiarrhythmic and cardioprotective agent, was investigated in vitro using fortified rat liver microsomal preparations. 2. Two metabolic products, N-desmethyl stobadine and stobadine N-oxide were isolated and identified by means of t.l.c.,g.l.c. -mass spectrometry, n.m.r. spectrometry and comparison with synthetic reference compounds. 3. Stobadine N-oxide was resolved into two optically active stereoisomers which were produced enzymically in approximately equal quantities. |
| Databáze: | OpenAIRE |
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