The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma
| Autor: | E. L. Newman, D. Hopwood, S. A. Ogston, B. V. Joypaul, A. Grant, A. Cuschieri, S. Qureshi, David P. Lane |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology Tumor suppressor gene Adenocarcinoma Biology Gastroenterology Stomach Neoplasms Internal medicine medicine Humans Lymph node Survival analysis Aged Neoplasm Staging Aged 80 and over Stomach Cancer Odds ratio Middle Aged Prognosis medicine.disease Survival Analysis medicine.anatomical_structure Oncology Immunohistochemistry Female Tumor Suppressor Protein p53 Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1994.182 |
| Popis: | We have studied the expression of p53 in 206 patients with gastric adenocarcinomas. A standard immunohistochemical technique employing the CM-1 anti-p53 polyclonal antibody was applied to the routinely fixed and paraffin-embedded material from these tumours; overexpression of p53 was defined as positive nuclear staining: 46% (94/206) of gastric carcinomas expressed high levels of p53. There was no significant correlation between p53 positivity and the tumour grade, growth pattern, the Lauren type or lymph node metastases. Correlation with disease stage was only marginally significant (P = 0.05). Life table analysis revealed a highly significant association between p53 expression and survival (P = 0.0062), the odds ratio of death being 1.89 (95% confidence interval 1.33-2.69). The overall 5-year survival of patients with p53-positive tumours was 3% compared with 16% for those with p53-negative tumours (median survival time being 5.6 and 11.4 months respectively). These data suggest that overexpression of the p53 oncoprotein is an independent marker of shortened survival in gastric cancer patients. Images Figure 1 Figure 2 |
| Databáze: | OpenAIRE |
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