V3 Spinal Neurons Establish a Robust and Balanced Locomotor Rhythm during Walking
| Autor: | Simon Gosgnach, Martyn Goulding, Jason R.B. Dyck, Guillermo M. Lanuza, Ying Zhang, Chen-Ming Fan, Keir G. Pearson, Turgay Akay, Sujatha Narayan, Tomoko Velasquez, Bayle Shanks, Eric J. Geiman |
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| Jazyk: | angličtina |
| Předmět: |
CIENCIAS MÉDICAS Y DE LA SALUD
Neuroscience(all) Commissural Interneurons Neurociencias interneuron Biology Neurotransmission MOLNEURO 03 medical and health sciences 0302 clinical medicine Rhythm Locomotor rhythm medicine Circadian rhythm 030304 developmental biology Balance (ability) 0303 health sciences General Neuroscience spinal cord purl.org/becyt/ford/3.1 [https] Spinal cord locomotion Medicina Básica medicine.anatomical_structure CPG Excitatory postsynaptic potential purl.org/becyt/ford/3 [https] Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2008.09.027 |
| Popis: | A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3-mediated neurotransmission is selectively blocked by the expression of the tetanus toxin light chain subunit (TeNT), the regularity and robustness of the locomotor rhythm is severely perturbed. A similar degeneration in the locomotor rhythm occurs when the excitability of V3-derived neurons is reduced acutely by ligand-induced activation of the allatostatin receptor. The V3-derived neurons additionally function to balance the locomotor output between both halves of the spinal cord, thereby ensuring a symmetrical pattern of locomotor activity during walking. We propose that the V3 neurons establish a regular and balanced motor rhythm by distributing excitatory drive between both halves of the spinal cord. Fil: Zhang, Ying. Salk Institute for Biological Studies; Estados Unidos Fil: Narajan, Sujatha. Salk Institute for Biological Studies; Estados Unidos Fil: Geiman, Eric. Salk Institute for Biological Studies; Estados Unidos Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Salk Institute for Biological Studies; Estados Unidos Fil: Velasquez, Tomoko. Salk Institute for Biological Studies; Estados Unidos Fil: Shanks, Bayle. Salk Institute for Biological Studies; Estados Unidos Fil: Akay, Turgay. University of Alberta; Canadá Fil: Dyck, Jason. University of Alberta; Canadá Fil: Pearson, Keir. University of Alberta; Canadá Fil: Gosgnach, Simon. University of Alberta; Canadá Fil: Fan, Chen-Ming. University Of Carnegie Mellon; Estados Unidos Fil: Goulding, Martyn. Salk Institute for Biological Studies; Estados Unidos |
| Databáze: | OpenAIRE |
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