| Autor: |
Manesh Shah, David Kainer, B Kirtley Amos, Piet Jones, Bruce J. Aronow, Omar Demerdash, Armin Geiger, Alexis Mitelpunkt, Kang Jin, John Pestian, Daniel Jacobson, Eric E. Bardes, Christiane Alvarez, Erica T. Prates, Michael R. Garvin, Mirko Pavicic |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
Using a Systems Biology approach, we integrated genomic, transcriptomic, proteomic, and molecular structure information to provide a holistic understanding of the COVID-19 pandemic. The expression data analysis of the Renin Angiotensin System indicates mild nasal, oral or throat infections are likely and that the gastrointestinal tissues are a common primary target of SARS-CoV-2. Extreme symptoms in the lower respiratory system likely result from a secondary-infection possibly by a comorbidity-driven upregulation of ACE2 in the lung. The remarkable differences in expression of other RAS elements, the elimination of macrophages and the activation of cytokines in COVID-19 bronchoalveolar samples suggest that a functional immune deficiency is a critical outcome of COVID-19. We posit that using a non-respiratory system as a major pathway of infection is likely determining the unprecedented global spread of this coronavirus.One Sentence SummaryA Systems Approach Indicates Non-respiratory Pathways of Infection as Key for the COVID-19 Pandemic |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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