Inhibitory effects of intravenous lansoprazole 30 mg and pantoprazole 40 mg twice daily on intragastric acidity in healthy Chinese volunteers: A randomized, open-labeled, two-way crossover study
| Autor: | Yan-Fang Gong, Xian-Bao Zhan, Li Zhen, Zhuan Liao, Shen Gao, Zhao-Shen Li, Jun Gao, Pei Liu, Xiao-Rong Guo |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male China Gastric acidity intravenous administration pantoprazole Lansoprazole Pharmacology Polymerase Chain Reaction 2-Pyridinylmethylsulfinylbenzimidazoles Gastric Acid Pantoprazole 40 MG Reference Values Clinical Research intragastric acidity medicine Humans Base sequence Infusions Intravenous DNA Primers Pantoprazole Cross-Over Studies Base Sequence business.industry General Medicine Hydrogen-Ion Concentration Anti-Ulcer Agents lansoprazole Crossover study volunteers Reference values Gastric acid Female business medicine.drug |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1234-1010 |
| DOI: | 10.12659/msm.882468 |
| Popis: | Summary Background Until now there has been no study that directly compares the effect of lansoprazole and pantoprazole administered intravenously on intragastric acidity. The aim of this study is to compare the effect of lansoprazole (30 mg) and pantoprazole (40 mg) administered intravenously on gastric acidity. Material/Methods Helicobacter pylori-negative healthy volunteers were recruited in this open-label, randomized, two-way crossover, single centre study. Lansoprazole at 30 mg or pantoprazole at 40 mg was intravenously administered twice daily for 5 consecutive days with at least a 14-day washout interval. Twenty-four-hour intragastric pH was continuously monitored on days 1 and 5 of each dosing period. Results Twenty-five volunteers completed the 2 dosing periods. The mean intragastric pH values were higher in subjects treated with lansoprazole than those with pantoprazole on both day 1 (6.41±0.14 vs. 5.49±0.13, P=0.0003) and day 5 (7.09±0.07 vs. 6.64±0.07, P=0.0002). Significantly higher percentages of time with intragastric pH >4 and pH >6 were found in the subjects treated with lansoprazole than those with pantoprazole on day 1 (pH >4, 87.12±4.55% vs. 62.28±4.15%, P=0.0012; pH >6, 62.12±4.12% vs. 47.25±3.76%, P=0.0216) and pH >6 on day 5 (76.79±3.77% vs. 58.20±3.77%, P=0.0025). Conclusions Intravenous lansoprazole produces a longer and more potent inhibitory effect on intragastric acidity than does intravenous pantoprazole. |
| Databáze: | OpenAIRE |
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