Correction to: The elevated levels of urinary angiotensinogen are correlated with the severity of idiopathic membranous nephropathy
| Autor: | Danxia Zheng, Yue Wang, Liyuan Tao, Yimu Zheng, Ziyong Tang, Yanhong Guo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Nephrology
Adult medicine.medical_specialty Adolescent Urinary system 030232 urology & nephrology MEDLINE Angiotensinogen Mistake 030204 cardiovascular system & hematology lcsh:RC870-923 Glomerulonephritis Membranous Severity of Illness Index 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Medicine Humans Serum Albumin Aged business.industry Nephrosis Lipoid Correction Middle Aged lcsh:Diseases of the genitourinary system. Urology Idiopathic Membranous Nephropathy Proteinuria Cross-Sectional Studies Case-Control Studies business Biomarkers Glomerular Filtration Rate |
| Zdroj: | BMC Nephrology BMC Nephrology, Vol 20, Iss 1, Pp 1-1 (2019) |
| ISSN: | 1471-2369 |
| Popis: | Immunosuppressive treatment will predispose an idiopathic membranous nephropathy (iMN) patient to opportunistic infections. Disease severity is one of the main concerns for making the treatment decision. Urinary angiotensinogen (UAGT) level has been shown highly correlated with intrarenal renin-angiotensin system (RAS) activity and severity of chronic kidney diseases (CKD). We aimed to test the relationship between the UAGT level and the severity of iMN.This cross-sectional study included a total of 48 biopsy-proven iMN patients, 46 minimal change disease (MCD) patients, and 44 healthy volunteers. The clinical and laboratory data and urine samples were collected from all subjects before the use of RAS inhibitors. We determined the UAGT levels with a method of enzyme-linked immunosorbent assay.The UAGT levels were not different between the iMN (277.05 ± 61.25, μg/g.Cr) and MCD patients (244.19 ± 40.24, μg/g.Cr), but both of them were significantly higher than those of healthy controls (6.85 ± 1.10, μg/g.Cr). UAGT levels were correlated negatively with serum albumin (r = - 0.393, p = 0.006) and estimated glomerular filtration rate (eGFR) (r = - 0.352, p = 0.014) and positively with 24-h proteinuria (r = 0.614, p 0.001) in iMN patients but not in MCD patients. Multivariate linear regression analysis revealed that only proteinuria independently determinate the levels of UAGT (β = 0.649, p 0.001) in iMN patients.UAGT levels were correlated negatively with serum albumin and glomerular filtration rate and positively with proteinuria in iMN patients at the onset. This suggests that elevated levels of UAGT are associated with the severity of iMN. The UAGT level may be used as a cofactor for deciding immunosuppressive therapy in iMN patient. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink