Robust intrathymic development of regulatory T cells in young NOD mice is rapidly restrained by recirculating cells
| Autor: | Ariel Galindo‐Albarrán, Olivier Joffre, Joost P. M. van Meerwijk, Ellen A. Robey, Paola Romagnoli, Jeremy C. Santamaria, Julie Darrigues |
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| Přispěvatelé: | Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Station d'écologie théorique et expérimentale (SETE), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), University of California [Berkeley], University of California |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male thymic niche Immunology Population Regulatory T-Lymphocytes chemical and pharmacologic phenomena Thymus Gland Biology T-Lymphocytes Regulatory regulatory T cells 03 medical and health sciences Mice 0302 clinical medicine Mice Inbred NOD thymus [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Immune Tolerance inbred mouse strains Immunology and Allergy Animals education NOD mice education.field_of_study tolerance hemic and immune systems 030104 developmental biology Diabetes Mellitus Type 1 030215 immunology |
| Zdroj: | European Journal of Immunology European Journal of Immunology, Wiley-VCH Verlag, 2020, pp.1-14. ⟨10.1002/eji.202048743⟩ |
| ISSN: | 0014-2980 1521-4141 |
| DOI: | 10.1002/eji.202048743⟩ |
| Popis: | International audience; Regulatory T lymphocytes (Treg) play a vital role in the protection of the organism against autoimmune pathology. It is therefore paradoxical that comparatively large numbers of Treg were found in the thymus of type I diabetes-prone NOD mice. The Treg population in the thymus is composed of newly developing cells and cells that had recirculated from the periphery back to the thymus. We here demonstrate that exceptionally large numbers of Treg develop in the thymus of young, but not adult, NOD mice. Once emigrated from the thymus, an unusually large proportion of these Treg is activated in the periphery, which causes a particularly abundant accumulation of recirculating Treg in the thymus. These cells then rapidly inhibit de novo development of Treg. The proportions of developing Treg thus reach levels similar to or lower than those found in most other, type 1 diabetes-resistant, inbred mouse strains. Thus, in adult NOD mice the particularly large Treg-niche is actually composed of mostly recirculating cells and only few newly developing Treg. |
| Databáze: | OpenAIRE |
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