Barrier damaging effects of n-propanol in occlusion-modified tandem repeated irritation test: Modulation by exposure factors and atopic skin disease

Autor: Ivone Jakasa, Tobias W. Fischer, Sanja Kezic, Tasja Stilla, Maryam Soltanipoor, Irena Angelova-Fischer
Přispěvatelé: Coronel Institute of Occupational Health, Graduate School, APH - Personalized Medicine, APH - Quality of Care, APH - Societal Participation & Health
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
Erythema
Hand Sanitizers
natural moisturizing factors
Cumulative Exposure
Physiology
Dermatology
1-Propanol
medicine.disease_cause
Dermatitis
Atopic
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
irritant contact dermatitis
In vivo
Risk Factors
Occupational Exposure
Occlusion
medicine
Immunology and Allergy
Humans
030212 general & internal medicine
skin barrier
Barrier function
Skin Tests
alcohol-based hand disinfectants
Transepidermal water loss
integumentary system
atopic dermatitis
business.industry
alcohol-based hand disinfectants
atopic dermatitis
irritant contact dermatitis
natural moisturizing factors
skin barrier
Atopic dermatitis
medicine.disease
Water Loss
Insensible
Dermatitis
Occupational
Case-Control Studies
Dermatitis
Irritant
Female
medicine.symptom
Irritation
business
Zdroj: Contact dermatitis, 82(1), 1-9. Wiley-Blackwell
ISSN: 0105-1873
DOI: 10.1111/cod.13368
Popis: Background Recent studies provide evidence for significant and previously underestimated barrier damaging effects of repeated exposure to 60% n-propanol in healthy skin in vivo. Objectives To investigate further the cumulative effects of a range of n-propanol concentrations relevant at the workplace in healthy and atopic dermatitis (AD) individuals, and study the modulation of the outcomes by co-exposure and host-related factors. Methods Healthy adult and AD volunteers were exposed to n-propanol concentrations from 30% to 75% in occlusion-modified tandem repeated irritation test with measurements of erythema, transepidermal water loss, capacitance, and the natural moisturizing factor (NMF) levels at baseline and after 96 hours. Results n-Propanol exerted significant barrier damaging effects even at the lowest concentration in both groups. Exposure to all n-propanol concentrations significantly reduced the NMF levels. Preceding low-grade trauma by occlusion/water exposure reduced the skin irritation threshold in both groups. The differences in the severity of the barrier function impairment after exposure to the same concentrations under the same conditions between the AD and control groups were significant. Conclusions The negative effects of cumulative exposure to n-propanol in healthy and atopic skin shown in the study suggest the need for critical re-evaluation of its irritant properties in vivo.
Databáze: OpenAIRE
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