The association between toxic pesticide environmental exposure and Alzheimer's disease: A scientometric and visualization analysis
| Autor: | Jingdong Zhang, Ruying Fang, Yanan Li, Luping Jiang, Chaoyang Liu, Fei Li, Zehua Liu, Honghu Li |
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| Rok vydání: | 2020 |
| Předmět: |
Environmental Engineering
Bibliometric analysis Health Toxicology and Mutagenesis 0208 environmental biotechnology 02 engineering and technology Disease 010501 environmental sciences 01 natural sciences Alzheimer Disease Environmental health Environmental Chemistry Medicine Humans Israel Pesticides Association (psychology) Knowledge structure 0105 earth and related environmental sciences business.industry Public Health Environmental and Occupational Health General Medicine General Chemistry Environmental exposure Environmental Exposure Pesticide Pollution United States 020801 environmental engineering Hot topics Bibliometrics Assessment methods business |
| Zdroj: | Chemosphere. 263 |
| ISSN: | 1879-1298 |
| Popis: | Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. The association between environmental factors (e.g., pesticide) and AD has attracted considerable attention. However, no systematic analysis has been performed and make it difficult to provide deeper insights of AD correlated with pesticide exposure. Hence, this study utilized a bibliometric and visual approach that included map collaborations, co-citations, and keywords, to identifying the knowledge structure, hot topics and the research trends based on 372 publications from the Web of Science Core Collection and PubMed databases. The results showed that 116 institutions from 52 countries published articles in this field. The United States and Israel played a leading role with numerous publications in related journals, as well as prolific institutions and authors, respectively. Three hot topics in pesticide-induced AD were recognized based on co-occurrence keywords detection, including acetylcholinesterase (AChE) inhibitor, oxidative stress, and AChE. Moreover, analysis of keywords burst suggests that some potential molecular mechanisms and therapy targets of pesticide-induced AD, especially for mitochondrial dysfunction and monoamine oxidase-B (MAO-B) that catalyzes the oxidative deamination and causes oxidative stress, are emerging trends. In addition, the study of various pesticides and the assessment method of pesticide exposure will step forward as well. To the best of our knowledge, this study is the first to specifically visualize the relationship between AD and pesticide exposure and to predict potential future research directions. |
| Databáze: | OpenAIRE |
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