Bacterial resistance to antimicrobial peptides an evolving phenomenon
| Autor: | Caleb M Agbale, Osmel Fleitas, Octavio L. Franco |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Bacteria Protein Stability medicine.drug_class Cell Membrane 030106 microbiology Antimicrobial peptides Antibiotics Down-Regulation Bacterial Infections Computational biology Biology Bacterial Physiological Phenomena Antimicrobial Protein Transport 03 medical and health sciences Broad spectrum Antibiotic resistance Osmotic Pressure Drug Design Drug Resistance Bacterial Proteolysis medicine Humans Antimicrobial Cationic Peptides |
| Zdroj: | Frontiers in Bioscience. 21:1013-1038 |
| ISSN: | 1093-4715 1093-9946 |
| DOI: | 10.2741/4438 |
| Popis: | Bacterial resistance to conventional antibiotics is currently a real problem all over the world, making novel antimicrobial compounds a real research priority. Some of the most promising compounds found to date are antimicrobial peptides (AMPs). The benefits of these drugs include their broad spectrum of activity that affects several microbial processes, making the emergence of resistance less likely. However, bacterial resistance to AMPs is an evolving phenomenon that compromises the therapeutic potential of these compounds. Therefore, it is mandatory to understand bacterial mechanisms of resistance to AMPs in depth, in order to develop more powerful AMPs that overcome the bacterial resistance response. |
| Databáze: | OpenAIRE |
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