Alternative Watson–Crick Synthetic Genetic Systems
| Autor: | Mariko F. Matsuura, Roberto Laos, Shuichi Hoshika, Ryan W. Shaw, Nilesh B. Karalkar, Diego Fajardo, Patricia Moussatche, Steven A. Benner |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Value (ethics) Models Genetic Emerging technologies Genetic systems Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid DNA Biology 010402 general chemistry Diagnostic tools 01 natural sciences Data science General Biochemistry Genetics and Molecular Biology 0104 chemical sciences Evolution Molecular 03 medical and health sciences Synthetic biology 030104 developmental biology Chemistry (relationship) Adaptation (computer science) Base Pairing Perspectives |
| Zdroj: | Cold Spring Harbor Perspectives in Biology |
| ISSN: | 1943-0264 |
| DOI: | 10.1101/cshperspect.a023770 |
| Popis: | In its "grand challenge" format in chemistry, "synthesis" as an activity sets out a goal that is substantially beyond current theoretical and technological capabilities. In pursuit of this goal, scientists are forced across uncharted territory, where they must answer unscripted questions and solve unscripted problems, creating new theories and new technologies in ways that would not be created by hypothesis-directed research. Thus, synthesis drives discovery and paradigm changes in ways that analysis cannot. Described here are the products that have arisen so far through the pursuit of one grand challenge in synthetic biology: Recreate the genetics, catalysis, evolution, and adaptation that we value in life, but using genetic and catalytic biopolymers different from those that have been delivered to us by natural history on Earth. The outcomes in technology include new diagnostic tools that have helped personalize the care of hundreds of thousands of patients worldwide. In science, the effort has generated a fundamentally different view of DNA, RNA, and how they work. |
| Databáze: | OpenAIRE |
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