Multiple Phosphatases Regulate Carbon Source-Dependent Germination and Primary Metabolism inAspergillus nidulans
| Autor: | Neil Andrew Brown, Gustavo H. Goldman, Leandro José de Assis, Taisa Magnani Dinamarco, Marcela Savoldi, Laure Nicolas Annick Ries |
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| Rok vydání: | 2015 |
| Předmět: |
Glycerol
Hypha glucose metabolism Citric Acid Cycle Investigations Aspergillus nidulans phosphatase Neurospora crassa Oxygen Consumption Gene Expression Regulation Fungal Genetics Cluster Analysis Ketoglutarate Dehydrogenase Complex Molecular Biology Genetics (clinical) Ethanol biology Gene Expression Profiling Cell Cycle Trehalose Metabolism Spores Fungal biology.organism_classification Pyruvate dehydrogenase complex Carbon Phosphoric Monoester Hydrolases GERMINAÇÃO Citric acid cycle Glucose germination Biochemistry Germination Mutation Basal Metabolism Signal transduction Metabolic Networks and Pathways |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP G3: Genes|Genomes|Genetics |
| ISSN: | 2160-1836 |
| DOI: | 10.1534/g3.115.016667 |
| Popis: | Aspergillus nidulans is an important mold and a model system for the study of fungal cell biology. In addition, invasive A. nidulans pulmonary infections are common in humans with chronic granulomatous disease. The morphological and biochemical transition from dormant conidia into active, growing, filamentous hyphae requires the coordination of numerous biosynthetic, developmental, and metabolic processes. The present study exhibited the diversity of roles performed by seven phosphatases in regulating cell cycle, development, and metabolism in response to glucose and alternative carbon sources. The identified phosphatases highlighted the importance of several signaling pathways regulating filamentous growth, the action of the pyruvate dehydrogenase complex as a metabolic switch controlling carbon usage, and the identification of the key function performed by the α-ketoglutarate dehydrogenase during germination. These novel insights into the fundamental roles of numerous phosphatases in germination and carbon sensing have provided new avenues of research into the identification of inhibitors of fungal germination, with implications for the food, feed, and pharmaceutical industries. |
| Databáze: | OpenAIRE |
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