Genetic and Environmental Dispositions for Cardiovascular Variability: A Pilot Study

Autor:	Biljana Obrenovic-Kircanski, Vladimir Milicevic, Radmila Karan, Milos Velinovic, Dejan Nikolic, Suzana Cvjeticanin, Natasa Kovacevic-Kostic
Rok vydání:	2018
Předmět:	medicine.medical_specialty lcsh:Medicine CAD 030204 cardiovascular system & hematology blood groups Article homozygously-recessive characteristics Coronary artery disease 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus ABO blood group system Hyperlipidemia medicine risk factors cardiovascular diseases 030212 general & internal medicine Control sample Blood type variability business.industry lcsh:R Significant difference General Medicine medicine.disease 3. Good health Cardiology business coronary artery disease
Zdroj:	Journal of Clinical Medicine Volume 7 Issue 9 Journal of Clinical Medicine, Vol 7, Iss 9, p 232 (2018)
ISSN:	2077-0383
Popis:	Background: The aim of our study was to evaluate the degree of genetic homozygosity in the group of patients with coronary artery disease (CAD), as well as to evaluate morphogenetic variability in CAD patients regarding the presence of investigated risk factors (RF) compared to a control sample of individuals. Additionally, we aimed to evaluate the distribution of ABO blood type frequencies between tested samples of individuals. Methods: This study analyzed individual phenotype and morphogenetic variability of 17 homozygously-recessive characteristics (HRC), by using HRC test in a sample of 148 individuals in CAD patients group and 156 individuals in the control group. The following RF were analyzed: hypertension, diabetes mellitus, hyperlipidemia, and smoking. Results: The mean value of HRC in CAD patients is significantly higher, while variability decreases compared to the control sample (CAD patients: 4.24 ± 1.59, control sample: 3.75 ± 1.69 VCAD-patients = 37.50%, VC = 45.07%). There is a significant difference in individual variations of 17 HRC between control sample and CAD patients (&chi 2 = 169.144 p < 0.01), which points out to different variability for tested genes. Mean values of HRC significantly differed in CAD patients in regard to the number of RF present. A blood type (OR = 1.75) is significant predictor for CAD, while O blood type (OR = 0.43) was significantly associated with controls. Conclusion: There is a higher degree of recessive homozygosity in CAD patients versus individuals in the control sample, and the presence of significant variations in the degree of recessive homozygosity as the number of tested RF increases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d68586c2bc38cb0c0490846579a53d https://doi.org/10.3390/jcm7090232 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.