Monocytosis as a prognostic factor for survival in stage IB and IIA cervical cancer
| Autor: | Byung Su Kwon, Yong Il Ji, Suk Bong Koh, Sanghoon Kwon, Heung Yeol Kim, Ki Hyung Kim, Sungwook Chun, Hong-Bae Kim, Wan Kyu Eo, Ji Young Lee, Jeong Namkung |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Cervical cancer medicine.medical_specialty Multivariate analysis Uterine cervical neoplasms business.industry Proportional hazards model Hazard ratio medicine.disease Monocytes 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Monocytosis 030220 oncology & carcinogenesis Internal medicine White blood cell Cohort Medicine business Lymph node Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| Popis: | Objective: To measure hematologic parameters derived from the white blood cell (WBC) count and differential count (DC) as prognostic factors for survival in patients with stage IB and IIA cervical cancer. Methods: We retrospectively examined demographic, clinicopathologic, and laboratory parameters in a cohort of 233 patients with International Federation of Gynecology and Obstetrics stage IB and IIA cervical cancer who underwent surgical resection. We further assessed the effects of the WBC count and DC-derived hematologic parameters on progression-free survival (PFS) and overall survival (OS) after controlling for other parameters. Results: Patients were followed up for a median of 46.6 months (range, 9-142 months). The Kaplan-Meier estimates of PFS and OS at 5 years were 88.5% and 92.3%, respectively. In a multivariate analysis, we identified the absolute monocyte count (AMC) (hazard ratio [HR], 11.78; P |
| Databáze: | OpenAIRE |
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