Skeletal muscle perfusion measured by positron emission tomography during exercise
| Autor: | Antoon T. M. Willemsen, Willem Vaalburg, G.J. Verkerke, Gerhard Rakhorst, Jaap Lubbers, Anne M. J. Paans, W. Ament |
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| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG, Extremities Pain and Disability (EXPAND) |
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Time Factors Physiology Clinical Biochemistry Isometric exercise DISEASE Functional Laterality Calf muscles Capillary Permeability GASTROCNEMIUS-MUSCLE Gastrocnemius muscle Oxygen Radioisotopes Physiology (medical) COMPARTMENTS medicine skeletal muscle perfusion Humans Muscle Skeletal Leg muscle exercise BLOOD-FLOW Anatomy Cross-Sectional medicine.diagnostic_test business.industry Water Skeletal muscle Anatomy Blood flow Middle Aged PET medicine.anatomical_structure Regional Blood Flow Positron emission tomography Injections Intravenous Exercise Test RAT business Perfusion Gastrocnemius medialis Muscle Contraction Tomography Emission-Computed |
| Zdroj: | Pflugers archiv-European journal of physiology, 436(5), 653-658. SPRINGER |
| ISSN: | 1432-2013 0031-6768 |
| DOI: | 10.1007/s004240050685 |
| Popis: | The applicability of (H2O)-O-15-positron emission tomographic (PET) imaging for the assessment of skeletal muscle perfusion during exercise was investigated in five healthy subjects performing intermittent isometric contractions on a calf ergometer. The workload of the left calf muscles was kept constant in all exercises, while that of the right calf muscles was varied. During exercise (H2O)-O-15 distribution in the calf muscles was measured by PET. Radioactivity measured in the left calf muscles was used as a reference for the radioactivity measured in the right calf muscles. In all studies, muscles were delineated by uptake of radioactivity. Four subjects demonstrated high radioactivity in the gastrocnemius medialis muscle, in one subject high radioactivity was distributed over the triceps surae muscles. The observed muscles demonstrated also local foci of radioactivity indicating regionally enhanced tissue perfusion. The right-left ratio of radioactivity in the active muscles increased as a function of the load. We conclude that inter- and intramuscle perfusion differences can be measured during exercise by (H2O)-O-15-PET imaging. |
| Databáze: | OpenAIRE |
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