Facilitation of Sexual Receptivity by Ventromedial Hypothalamic Implants of the Antiprogestin RU 486
| Autor: | Jennifer Lipetz, Eric T. Pleim, Tara L. Steele, Ronald J. Barfield |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Lordosis medicine.drug_class Receptivity Sexual Behavior Animal Behavioral Neuroscience chemistry.chemical_compound Endocrinology Internal medicine medicine Animals Progesterone Drug Implants Neurons Brain Mapping Endocrine and Autonomic Systems Antagonist Drug Synergism Mifepristone medicine.disease Rats chemistry Ventromedial Hypothalamic Nucleus Hypothalamus Estrogen Ovariectomized rat Estradiol benzoate Female Psychology medicine.drug |
| Zdroj: | Hormones and Behavior. 27:488-498 |
| ISSN: | 0018-506X |
| DOI: | 10.1006/hbeh.1993.1035 |
| Popis: | RU 486 is known primarily as an antagonist to progestins and glucocorticoids. However, RU 486 has also been shown to have agonistic progestational properties in biochemical and behavioral studies. In the current study, RU 486 was implanted directly into tim ventromedial hypothalamus (VMH) to test for facilitative action on the receptive behavior of female ovariectomized Long-Evans rats primed with 5 μg of estradiol benzoate. Cannulae containing RU 486, progesterone (P), or empty cannulae were implanted 48 hr after estrogen priming. The lordosis quotient and the lordosis score were assessed 4 hr after the cannulae were lowered by a standardized test consisting of 10 mounts by a stimulus male. P and RU 486 significantly facilitated receptivity compared to blank implants in terms of lordosis quotient and lordosis score, with no significant difference between the hormone treatments. While only a single dose of each treatment was given in the current study, RU 486 facilitated lordosis when implanted to the VMH as well as progesterone in contrast to our previous results where the steroids were administered systemically. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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