An Adrenalectomy Mouse Model Reflecting Clinical Features for Chronic Fatigue Syndrome

Autor: Yoo Jin Jeon, Samuel Young Park, Jin-Seok Lee, Chang-Gue Son
Rok vydání: 2020
Předmět:
Lipopolysaccharides
Male
0301 basic medicine
medicine.medical_specialty
medicine.medical_treatment
lcsh:QR1-502
Hippocampus
chronic fatigue syndrome
Biochemistry
Article
lcsh:Microbiology
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Chronic fatigue syndrome
Animals
Medicine
Receptor
Prefrontal cortex
Molecular Biology
Serotonin Plasma Membrane Transport Proteins
Mice
Inbred ICR
Fatigue Syndrome
Chronic
Microglia
business.industry
animal model
Adrenalectomy
lipopolysaccharide
Brain
adrenalectomy
medicine.disease
Neurosecretory Systems
Disease Models
Animal
Poly I-C
030104 developmental biology
Endocrinology
medicine.anatomical_structure
chemistry
Polyinosinic:polycytidylic acid
Serotonin
business
030217 neurology & neurosurgery
polyinosinic: polycytidylic acid
Zdroj: Biomolecules, Vol 10, Iss 1, p 71 (2020)
Biomolecules
Volume 10
Issue 1
ISSN: 2218-273X
DOI: 10.3390/biom10010071
Popis: Chronic fatigue syndrome (CFS) is one of the most intractable diseases and is characterized by severe central fatigue that impairs even daily activity. To date, the pathophysiological mechanisms are uncertain and no therapies exist. Therefore, a proper animal model reflecting the clinical features of CFS is urgently required. We compared two CFS animal models most commonly used, by injection with lipopolysaccharide (LPS from Escherichia coli O111:B4) or polyinosinic: polycytidylic acid (poly I:C), along with bilateral adrenalectomy (ADX) as another possible model. Both LPS- and poly I:C-injected mice dominantly showed depressive behaviors, while ADX led to fatigue-like performances with high pain sensitivity. In brain tissues, LPS injection notably activated microglia and the 5-hydroxytryptamine (HT)1A receptor in the prefrontal cortex and hippocampus. Poly I:C-injection also remarkably activated the 5-HT transporter and 5-HT1A receptor with a reduction in serotonin levels in the brain. ADX particularly activated astrocytes and transforming growth factor beta (TGF-&beta
) 1 in all brain regions. Our results revealed that LPS and poly I:C animal models approximate depressive disorder more closely than CFS. We suggest that ADX is a possible method for establishing a mouse model of CFS reflecting clinical features, especially in neuroendocrine system.
Databáze: OpenAIRE
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