Attention-deficit hyperactivity disorder comorbidity and antidepressant resistance among patients with major depression: A nationwide longitudinal study

Autor: Shih-Jen Tsai, Mu Hong Chen, Kai Lin Huang, Tai Long Pan, Tung Ping Su, Wen Han Chang, Ya Mei Bai, Wei Chen Lin, Cheng Ta Li, Tzeng Ji Chen, Ju Wei Hsu
Rok vydání: 2016
Předmět:
Adult
Male
medicine.medical_specialty
Longitudinal study
Adolescent
Taiwan
Depressive Disorder
Treatment-Resistant
Young Adult
03 medical and health sciences
0302 clinical medicine
International Classification of Diseases
Risk Factors
Internal medicine
mental disorders
medicine
Humans
Attention deficit hyperactivity disorder
Pharmacology (medical)
Longitudinal Studies
Child
Psychiatry
Biological Psychiatry
Depression (differential diagnoses)
Pharmacology
Depressive Disorder
Major
Mental Disorders
Odds ratio
medicine.disease
Comorbidity
Antidepressive Agents
Confidence interval
030227 psychiatry
Psychiatry and Mental health
Socioeconomic Factors
Neurology
Attention Deficit Disorder with Hyperactivity
Anxiety
Antidepressant
Female
Neurology (clinical)
medicine.symptom
Psychology
030217 neurology & neurosurgery
Zdroj: European Neuropsychopharmacology. 26:1760-1767
ISSN: 0924-977X
Popis: The comorbidity between attention deficit hyperactivity disorder (ADHD) and major depression is common. However, the influence of ADHD comorbidity in the response or resistance to antidepressants remains unknown among patients with major depression. 1891 patients with major depression and ADHD and 1891 age-/sex-matched patients with major depression only were enrolled and followed for 1 year in our study. Use of antidepressants and ADHD medications during 1-year follow-up period were assessed. Antidepressant resistance was defined as treatment failure in two or more than two different antidepressants for adequate treatment dose and duration. Patients with major depression and ADHD had an increased risk of treatment resistance to antidepressants (odds ratio [OR]: 2.32, 95% confidence interval [CI]: 1.63-3.32) compared with patients with major depression only after adjusting for demographic characteristics and other psychiatric comorbidities. Regular treatment for ADHD would reduce this risk (OR: 1.76, 95% CI: 0.72-4.27). Anxiety (OR: 3.15, 95% CI: 2.24-4.44) and substance use (OR: 2.45, 95% CI: 1.16-5.17) disorders were also associated with an elevated likelihood of resistance to antidepressants during the follow-up. Patients who had dual diagnoses of major depression and ADHD were more likely to have treatment resistance to antidepressants compared with patients with major depression only. Prompt and regular treatment for ADHD would reduce this risk.
Databáze: OpenAIRE
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