Doxorubicin-loaded hollow gold nanospheres for dual photothermal ablation and chemoembolization therapy

Autor: Chun Li, Sanjay Gupta, Rahul A. Sheth, Cheng Hui Hsiao, Junjie Li, Marites P. Melancon, Diana S.-L. Chow, Xin Ji, Xiaoxia Wen, Elizabeth M. Whitley, Y. Andrew Wang
Rok vydání: 2020
Předmět:
Zdroj: Cancer Nanotechnology, Vol 11, Iss 1, Pp 1-16 (2020)
Cancer Nanotechnol
ISSN: 1868-6966
1868-6958
Popis: Background Doxorubicin-loaded hollow gold nanospheres (Dox@HAuNS) are a promising technology for simultaneous trans-arterial tumor-targeted chemotherapy delivery and thermal ablation. We evaluated the efficacy of intra-arterial delivery of Dox@HAuNS followed by photothermal ablation (PTA) in a rabbit model of liver cancer. Adult New Zealand white rabbits (N = 25) were inoculated with VX2 tumors into the left lobe of the liver. The animals were then randomized to sham surgery (N = 5), PTA only (N = 3), Dox@HAuNS only (N = 5), HAuNS + PTA (N = 5), and Dox@HAuNS + PTA (N = 7). Nanoparticles were delivered as an emulsion with Lipiodol (Guerbet, France) via a trans-arterial approach. Following nanoparticle delivery, PTA was performed using an 808-nm fibered laser at 1.5 W for 3 min. Thermography during PTA demonstrated a sustained elevation in tumoral temperature in both HAuNS + laser and Dox@HAuNS + laser treatment groups relative to animals that underwent laser treatment without prior nanoparticle delivery. Results There was a significant decrease in tumor volumes in all three treatment arms relative to control arms (P = 0.004). Concentrations of intratumoral doxorubicin were significantly greater in animals treated with laser compared to those that were not treated with laser (P Conclusions Doxorubicin-loaded HAuNS is a promising therapeutic agent for dual ablation/chemoembolization treatment of liver cancer.
Databáze: OpenAIRE
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