On- and off-exercise kinetics of cardiac output in response to cycling and walking in COPD patients with GOLD Stages I–IV
| Autor: | Ioannis Vogiatzis, Ioannis Nasis, Antonia Koutsoukou, Stauroula Spetsioti, Manos Alchanatis, Georgios Kaltsakas, Maria Koskolou, Eleni Kortianou, Maroula Vasilopoulou, Nikolaos Koulouris, Evgenia Cherouveim, Zafeiris Louvaris |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Cardiac output Physiology Haemodynamic response Matched-Pair Analysis Hemodynamics Walking Severity of Illness Index Pulmonary Disease Chronic Obstructive Heart Rate Reference Values Internal medicine Severity of illness Heart rate medicine Humans Cardiac Output Dynamic hyperinflation Exercise Aged COPD business.industry General Neuroscience Stroke Volume Stroke volume Middle Aged medicine.disease Adaptation Physiological Bicycling Case-Control Studies Respiratory Mechanics Cardiology Physical therapy Female business |
| Zdroj: | Respiratory Physiology & Neurobiology. 181:351-358 |
| ISSN: | 1569-9048 |
| DOI: | 10.1016/j.resp.2012.03.014 |
| Popis: | Exercise-induced dynamic hyperinflation and large intrathoracic pressure swings may compromise the normal increase in cardiac output (Q) in Chronic Obstructive Pulmonary Disease (COPD). Therefore, it is anticipated that the greater the disease severity, the greater would be the impairment in cardiac output during exercise. Eighty COPD patients (20 at each GOLD Stage) and 10 healthy age-matched individuals undertook a constant-load test on a cycle-ergometer (75% WRpeak) and a 6 min walking test (6MWT). Cardiac output was measured by bioimpedance (PhysioFlow, Enduro) to determine the mean response time at the onset of exercise (MRTon) and during recovery (MRToff). Whilst cardiac output mean response time was not different between the two exercise protocols, MRT responses during cycling were slower in GOLD Stages III and IV compared to Stages I and II (MRTon: Stage I: 45 ± 2, Stage II: 65 ± 3, Stage III: 90 ± 3, Stage IV: 106 ± 3 s; MRToff: Stage I: 42 ± 2, Stage II: 68 ± 3, Stage III: 87 ± 3, Stage IV: 104 ± 3 s, respectively). In conclusion, the more advanced the disease severity the more impaired is the hemodynamic response to constant-load exercise and the 6MWT, possibly reflecting greater cardiovascular impairment and/or greater physical deconditioning. |
| Databáze: | OpenAIRE |
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