Olfactory Mucosal Findings in Patients with Persistent Anosmia after Endoscopic Sinus Surgery
| Autor: | Heung Man Lee, Hyo Jin Park, Sang Hag Lee, Jong Ouck Choi, Hyun Ho Lim |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Olfactory Receptor Cell Anosmia Olfaction Disorders 03 medical and health sciences Olfactory mucosa Nasal Polyps Polyps Postoperative Complications 0302 clinical medicine Olfactory Mucosa Reference Values Paranasal Sinuses Biopsy medicine Humans Nasal polyps Sinusitis 030223 otorhinolaryngology Olfactory Region medicine.diagnostic_test business.industry Endoscopy General Medicine Middle Aged medicine.disease medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Chronic Disease Respiratory epithelium Female medicine.symptom business Olfactory epithelium |
| Zdroj: | Annals of Otology, Rhinology & Laryngology. 109:720-725 |
| ISSN: | 1943-572X 0003-4894 |
| DOI: | 10.1177/000348940010900804 |
| Popis: | Sixty-three biopsy specimens were obtained from the olfactory region of 15 patients with persistent anosmia and 6 patients with normosmia after sinus surgery. Immunohistochemical examination of all specimens with microtubule-associated protein 5 (MAP5) antisera demonstrated olfactory epithelium in 11 of 18 specimens from normosmic patients and in 12 of 45 samples from anosmic patients. There was a significant difference in the proportion of specimens containing olfactory epithelium between the two groups of patients. In normosmic patients, most of the biopsy samples contained normal-appearing olfactory tissue. However, 2 main patterns of histologic findings were noted in the olfactory mucosa of anosmic patients. First, the olfactory receptor cells were remarkably decreased in number. Second, the orderly arrangement of cells characteristic of normal olfactory epithelium was lost, demonstrating a degenerative appearance. These data suggest that olfactory epithelium can be degenerated even in chronic sinusitis and thereafter extensively replaced with respiratory epithelium, resulting in increased sampling error. Moreover, an unimproved olfactory deficit after sinus surgery may be due to the abnormalities observed at the olfactory epithelium level. |
| Databáze: | OpenAIRE |
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